Cox model with interval-censored covariate in cohort studies

Biometrical Journal. Biometrische Zeitschrift
Soohyun AhnMitchell S Elkind

Abstract

In cohort studies the outcome is often time to a particular event, and subjects are followed at regular intervals. Periodic visits may also monitor a secondary irreversible event influencing the event of primary interest, and a significant proportion of subjects develop the secondary event over the period of follow-up. The status of the secondary event serves as a time-varying covariate, but is recorded only at the times of the scheduled visits, generating incomplete time-varying covariates. While information on a typical time-varying covariate is missing for entire follow-up period except the visiting times, the status of the secondary event are unavailable only between visits where the status has changed, thus interval-censored. One may view interval-censored covariate of the secondary event status as missing time-varying covariates, yet missingness is partial since partial information is provided throughout the follow-up period. Current practice of using the latest observed status produces biased estimators, and the existing missing covariate techniques cannot accommodate the special feature of missingness due to interval censoring. To handle interval-censored covariates in the Cox proportional hazards model, we propose an a...Continue Reading

References

Dec 29, 2000·Biometrics·E Goetghebeur, L Ryan
Jan 10, 2002·Statistics in Medicine·Rebecca A BetenskyM P Wand
Jan 17, 2003·Statistics in Medicine·Guadalupe GómezStephen W Lagakos
Jan 30, 2004·Statistics in Medicine·Peter C Austin, Jeffrey S Hoch
Sep 28, 2004·Statistics in Medicine·Klaus LangohrRobert Muga
Apr 15, 2008·Statistics in Medicine·Gina D'AngeloUNKNOWN GenIMS Investigators
Mar 3, 2012·Stroke; a Journal of Cerebral Circulation·Chirantan BanerjeeMitchell S V Elkind
Jan 1, 2012·Journal of Biometrics & Biostatistics·Abdus SattarNathan J Morris
Aug 12, 2014·Biometrical Journal. Biometrische Zeitschrift·Klaus Langohr, Guadalupe Gómez Melis

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