Abstract
The introduction of selective cyclooxygenase-2 inhibitors offered the promise of similar efficacy in pain control without the gastrointestinal effects associated with non-selective non-steroidal anti-inflammatory drugs (NSAIDs). By blocking prostacyclin formation but leaving platelet-derived thromboxane A2 generation unopposed, there is concern that the potential gastrointestinal benefit of cyclooxygenase-2-selective inhibitors may come at the cost of increased thrombotic risk. However, the differential effects of coxibs on blood pressure, endothelial function, oxidative stress, tissue factor expression, vascular smooth muscle proliferation and neointimal hyperplasia indicate a distinct heterogeneity among this class of drugs. Importantly, the observation of an excess cardiovascular risk with traditional NSAIDs in randomized clinical trials, meta-analysis and large-scale observational studies further highlights the need to scrutinize the entire class of anti-inflammatory drugs, including traditional NSAIDs, as rigorously as coxibs.
Citations
Sep 28, 2007·Comprehensive Therapy·Wasim HaqueHarry L Messmore
Sep 26, 2008·BMC Health Services Research·Nadia Barozzi, Susan E Tett
Sep 4, 2010·Research in Social & Administrative Pharmacy : RSAP·Kent E M GrovesNeil J MacKinnon
May 30, 2008·Journal of Pain and Symptom Management·Peggy A ComptonBruce D Naliboff
Nov 14, 2006·Internal Medicine Journal·T Woodruff
Jun 18, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·B K SharmaY S Prabhakar
Jul 5, 2007·The Annals of Pharmacotherapy·Javier C WaksmanScott D Phillips
Oct 3, 2014·Journal of Patient Safety·Cornelis A van den BogertKenneth G Saag
Dec 6, 2017·Postgraduate Medicine·Chris Walker, Luigi M Biasucci
Sep 2, 2008·European Journal of Heart Failure·Paul A ScottDavid L Scott
Nov 14, 2007·International Journal of Clinical Practice·G I VarugheseM Reddy
Dec 1, 2007·Arthritis and Rheumatism·Rachel B FryJeroan J Allison
Jul 29, 2010·Journal of Evaluation in Clinical Practice·Aneta PerićSandra Vezmar
Apr 18, 2019·International Journal of Immunopathology and Pharmacology·Mamdooh H GhoneumSudhanshu Agrawal
Jan 24, 2007·The Journal of Pharmacology and Experimental Therapeutics·Fumitaka KamachiKazuo Ohuchi
Sep 25, 2015·Medicine·Yu-Kang ChangChih-Cheng Hsu
Aug 8, 2009·British Journal of Clinical Pharmacology·Nadia BarozziSusan Tett
Dec 16, 2010·Journal of Thrombosis and Haemostasis : JTH·R RisseladaM C J M Sturkenboom
Aug 9, 2017·Frontiers in Pharmacology·Ping LiXin Chen
Jan 21, 2021·Expert Opinion on Pharmacotherapy·Kevin S Tang, Ankur D Shah
Jul 15, 2021·Journal of Immunology Research·Shirin AssarJavier Echeverría
Dec 26, 2007·Bioorganic & Medicinal Chemistry·Aurelio OrjalesM Teresa Núñez
May 4, 2010·American Heart Journal·Jiunn-Horng Kang, Herng-Ching Lin