Coxiella burnetii blood cultures from acute and chronic Q-fever patients.

Journal of Clinical Microbiology
D Musso, D Raoult

Abstract

Q fever, a worldwide zoonosis caused by Coxiella burnetii, may present as either an acute or a chronic disease. We correlated the results of 844 C. burnetii blood cultures with serological, clinical, and therapeutic data. C. burnetii was isolated from 17% of untreated patients with acute Q fever and from 53% of untreated patients with chronic Q fever. C. burnetii was not isolated from patients who were receiving antibiotics active against C. burnetii. For seven culture-positive patients with acute Q fever, serology was negative when C. burnetii was isolated. One patient with acute Q fever had a positive blood culture 25 days after the discontinuation of specific antibiotic therapy, and another had a positive blood culture after the resolution of symptoms. In one case of chronic Q fever, a positive blood culture resulted from noncompliance with treatment. The culture method described in this report is suitable for all laboratories with cell culture facilities. Our findings suggest that blood samples must be collected prior to the initiation of an antibiotic regimen if C. burnetii is to be successfully isolated.

References

Oct 1, 1977·Journal of Clinical Microbiology·K T Ripa, P A Mårdh
Aug 31, 1991·Lancet·M MicoudD Raoult
Feb 1, 1989·The American Journal of Tropical Medicine and Hygiene·M Marrero, D Raoult
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·D RaoultC Chiche-Portiche
Jul 1, 1987·Antimicrobial Agents and Chemotherapy·M R YeamanO G Baca
Jul 1, 1985·The Journal of Infection·T J Marrie
Mar 1, 1994·Clinical and Diagnostic Laboratory Immunology·H T DupontD Raoult
Jan 1, 1994·Nephron·F LeonettiY Berland
Feb 3, 1994·The New England Journal of Medicine·D Racult, A Stein
Jan 1, 1993·AIDS·D RaoultJ Salducci

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Citations

Jan 1, 1997·Scandinavian Journal of Infectious Diseases·Y Siegman-IgraI Shalit
Jan 9, 2001·Clinical Microbiology Reviews·P Brouqui, D Raoult
Jul 20, 2005·QJM : Monthly Journal of the Association of Physicians·J-M Rolain, D Raoult
Apr 4, 2012·Emerging Infectious Diseases·Linda M KampschreurJan Jelrik Oosterheert
May 26, 1999·Emerging Infectious Diseases·V S SerbezovV Voynova
Aug 19, 2015·Emerging Infectious Diseases·Linda M KampschreurUNKNOWN Dutch Q Fever Consensus Group
Dec 17, 2014·Medicine·Marcela González-Del VecchioEmilio Bouza
Oct 6, 2010·Epidemiology and Infection·H I J RoestD Raoult
Mar 24, 2012·Clinical and Vaccine Immunology : CVI·Linda M KampschreurPeter C Wever
Feb 23, 2011·Letters in Applied Microbiology·M G LockhartJ Stenos
Jul 17, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Botelho-NeversD Raoult
Jan 23, 1999·Annals of Neurology·Y SawaishiG Takada
Jan 1, 1997·International Journal of Antimicrobial Agents·T J Marrie, D Raoult
Oct 19, 1999·Journal of Clinical Microbiology·M L BirgD Raoult
Jun 1, 2021·Journal of Medical Imaging and Radiation Oncology·Pirathaban SivabalanRobert Norton
Aug 9, 2003·Journal of Clinical Microbiology·Florence FenollarDidier Raoult
Sep 6, 2003·Journal of Clinical Microbiology·Clarisse RoveryPhilippe Brouqui
Sep 10, 2010·Journal of Clinical Microbiology·Jeroen J H C TilburgCorné H W Klaassen
Jul 3, 1998·Journal of Clinical Microbiology·P E FournierD Raoult
Feb 12, 1998·Journal of Clinical Microbiology·G Q ZhangK Hirai
Jun 8, 2006·Journal of Clinical Microbiology·Petros C KarakousisJ Stephen Dumler
Oct 9, 1999·Clinical Microbiology Reviews·M Maurin, D Raoult
May 2, 2002·The Medical Clinics of North America·Elisa Choi

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