Abstract
Enteroviruses are known as major infectious agents for inflammatory heart diseases such as myocarditis and dilated cardiomyopathy (DCM). Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by replacement of right ventricular myocardium by fatty and fibrous tissue. In about 65% of patients inflammatory infiltrates suggest an inflammatory or infectious etiopathogenesis. To test this hypothesis, we investigated endomyocardial biopsies of patients with ARVC, with myocarditis or DCM, and from patients with non-inflammatory cardiac disorders for the presence of enteroviral genome. Enteroviral RNA with homology to coxsackieviruses type B was detected in 3 of 8 patients with ARVC (37.5%), in 7 of 23 patients with myocarditis or DCM (30.4%), but in none of 5 patient with non-infectious myocardial diseases (p < 0.05 compared to ARVC patients). These results support earlier suggestions that coxsackievirus infection of the myocardium is possibly related to the pathogenesis of ARVC.
Citations
Dec 12, 2001·Journal of the American College of Cardiology·C GemayelP D Thompson
Mar 1, 2002·Journal of the American College of Cardiology·Neil E BowlesJeffrey A Towbin
Jun 27, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·K M MeursJ A Towbin
Jun 30, 2000·The New England Journal of Medicine
May 17, 2002·Current Opinion in Cardiology·Gian Antonio Danieli, Alessandra Rampazzo
Jun 27, 2003·Current Opinion in Cardiology·Neil E Bowles, Jesus Vallejo
Oct 21, 2005·Der Internist·H-P SchultheissM Pauschinger
Jul 24, 2001·Anesthesiology·G FontaineR Frank
Sep 17, 2013·Journal of Veterinary Internal Medicine·K M MeursS P Tou
Apr 24, 2014·Cell Communication & Adhesion·Dipal M Patel, Kathleen J Green
Apr 30, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Dongdong QueLei Liu
Jan 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Fiorella CalabreseGaetano Thiene
Aug 28, 2004·Pediatric Clinics of North America·Jeffrey A Towbin
Aug 10, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·C Basso
Sep 29, 2017·Cardiovascular Research·Edgar T HoorntjeJ Peter van Tintelen
Jun 19, 2010·Circulation. Arrhythmia and Electrophysiology·Michael P RileyFrancis E Marchlinski
Oct 12, 2000·Circulation·P R FoxG Thiene
Apr 28, 2019·Nature Reviews. Cardiology·Karyn M AustinWilliam T Pu
Nov 2, 2002·Scandinavian Journal of Immunology·A TonioloT Onodera
Jun 29, 2002·Archives of Pathology & Laboratory Medicine·Irina Mikolaenko, Michael G Conner
Nov 16, 2021·Circulation·Babken AsatryanC Anwar A Chahal