PMID: 7538177Jun 1, 1995Paper

Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment

Journal of Virology
D R ShafrenR D Barry

Abstract

Receptor binding and subsequent cell-mediated internalization or disassembly are the initial steps in virus replication. Cell surface molecules that participate in this process are the primary determinants of virus tissue tropism. Monoclonal antibody blockade, immunoprecipitation, and DNA transfection were used to identify decay accelerating factor as a major cell attachment receptor for coxsackieviruses B1, B3, and B5. However, expression of human decay acceleration factor on the surface of nonpermissive murine fibroblasts led only to virus attachment without subsequent replication, and it was concluded that an additional cellular cofactor(s) is required to facilitate cell entry and subsequent replication.

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Citations

Apr 1, 1996·The Pediatric Infectious Disease Journal·K D Yang, H R Hill
Apr 20, 2001·Journal of Virology·I G GoodfellowD J Evans
Dec 26, 2001·The Journal of General Virology·O Brad SpillerB Paul Morgan
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