PMID: 2759903Aug 1, 1989Paper

CP-78,545, a new monocarboxylic acid ionophore antibiotic related to zincophorin and produced by a Streptomyces

The Journal of Antibiotics
J P DirlamT Sakakibara

Abstract

A new monocarboxylic acid ionophore antibiotic related to zincophorin, CP-78,545 (1), was found in the culture broth of Streptomyces sp. N731-45. CP-78,545 was extracted with organic solvents and purified by column chromatography. The metabolite, which is active in vitro against certain Gram-positive bacteria, as well as the anaerobe Treponema hyodysenteriae, and a coccidium Eimeria tenella, was isolated as a water insoluble magnesium salt (2) in 2:1 (ligand/metal) stoichiometry. The structure of CP-78,545 was elucidated by spectroscopic (NMR and MS) methods, and the relative stereochemistry was determined by single-crystal X-ray analysis of the cadmium salt (3). CP-78,545, i.e., 24-dehydrozincophorin, is unique since its molecular backbone contains a terminal double bond previously not found in other polyether ionophores.

Citations

Apr 16, 2013·BioMed Research International·Jacek Rutkowski, Bogumil Brzezinski
Jan 1, 1991·Critical Reviews in Biotechnology·C M Franco, L E Coutinho
Oct 24, 2003·Organic Letters·Magali DefosseuxJanine Cossy

Related Concepts

CP 78545
Antibiotics
Carboxylic Acids
Coccidiostats
Fermentation
Ionophores
Fungus Drug Sensitivity Tests
In Vivo NMR Spectroscopy
Streptomyces
X-Ray Diffraction

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