PMID: 1577662Mar 1, 1992Paper

CP-82,009, a potent polyether anticoccidial related to septamycin and produced by Actinomadura sp

The Journal of Antibiotics
J P DirlamA P Ricketts

Abstract

A new polyether antibiotic CP-82,009 (C49H84O17) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53676). Following purification by column chromatography and crystallization, the structure of CP-82,009 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-82,009 is among the most potent anticoccidial agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Serpulina (Treponema) hyodysenteriae.

Citations

Apr 16, 2013·BioMed Research International·Jacek Rutkowski, Bogumil Brzezinski
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson

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