PMID: 2380113Jun 1, 1990Paper

CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp

The Journal of Antibiotics
J P DirlamJ R Oscarson


A new polyether antibiotic CP-84,657 (C45H78O14) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53708). Following purification by column chromatography and crystallization, the structure of CP-84,657 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Treponema hyodysenteriae.


Jan 1, 1991·Critical Reviews in Biotechnology·C M Franco, L E Coutinho
Apr 16, 2013·BioMed Research International·Jacek Rutkowski, Bogumil Brzezinski
Apr 27, 2012·The Journal of Antibiotics·Yasuhiro IgarashiKoji Miyanouchi
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson

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