CpG Island Methylation in Sessile Serrated Adenomas Increases With Age, Indicating Lower Risk of Malignancy in Young Patients

Gastroenterology
Cheng LiuVicki Whitehall

Abstract

Among sessile serrated adenomas (SSAs) with identical histologic features, some never progress, whereas others become dysplastic and develop into invasive cancers. Development of the CpG island methylator phenotype is a feature of SSA progression; we examined the CIMP status of 448 SSAs and examined the association with patient clinical data. Overall, 190 SSAs were CpG island methylator phenotype-positive. CpG island methylator phenotype positivity was associated with older patient age (P < .001) and proximal polyp site (P < .001), but not with patient sex (P = .94) or polyp size (P = .34). These results might be used to improve SSA surveillance guidelines.

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Citations

Jun 26, 2020·Journal of Pathology and Translational Medicine·Jung Ho Kim, Gyeong Hoon Kang
May 10, 2020·The American Journal of Surgical Pathology·Takuma OkamuraShigeki Sekine
Jan 2, 2019·Gastroenterology Research and Practice·Catherine E Bond, Vicki L J Whitehall
Jul 25, 2019·Cancers·Fatima Domenica Elisa De PalmaFrancesco Salvatore
Jun 16, 2019·Clinical Epigenetics·Cheng LiuVicki L J Whitehall
Apr 28, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rish K PaiChristophe Rosty
May 10, 2020·Cancers·Lochlan J FennellVicki L J Whitehall
May 23, 2020·Gastrointestinal Endoscopy Clinics of North America·Joseph C Anderson, Amitabh Srivastava

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