CpG motif-based adjuvant as a replacement for Freund's complete adjuvant in a recombinant LHRH vaccine

Vaccine
Valéria A ConfortiJ J Reeves

Abstract

This study compared: (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n=8 heifers/group) were: one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. All vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization.

References

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Jul 24, 2007·Vaccine·Valéria A ConfortiJerry J Reeves

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Citations

Dec 2, 2008·International Journal of Pharmaceutics·Leonardo SáenzJosé L Arias
May 4, 2011·Journal of Applied Toxicology : JAT·Li LiuBo Li
Apr 24, 2010·Molecular and Cellular Endocrinology·E A McLaughlin, R J Aitken
Oct 4, 2018·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·David Hawksworth
Oct 23, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Nancy C BoedekerJanine L Brown

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