CpG oligodeoxynucleotides directly induce CXCR3 chemokines in human B cells

Biochemical and Biophysical Research Communications
Atsushi KatoKenji Matsumoto

Abstract

CpG oligodeoxynucleotides (CpG ODN) are known to elicit Th1 immune responses via TLR9. However, the precise mechanisms through which B cells are involved in this phenomenon are not fully understood. We investigated the effect of CpG ODN on the induction of Th1-chemoattractant CXCR3 chemokines, IP-10, Mig, and I-TAC, in B cells. Cells from the RPMI 8226 human B cell line and human peripheral B cells were stimulated with three distinct classes of CpG ODN. As a result, CXCR3 chemokines were strongly up-regulated by CpG-B and CpG-C, but only weakly by CpG-A. Though CXCR3 chemokines are known to be induced by IFNs, blocking mAbs against IFN receptors did not inhibit their induction by CpG-B. Induction of CXCR3 chemokines was blocked by two NF-kappaB inhibitors and a p38 inhibitor. These results strongly suggest that CXCR3 chemokines are directly induced by CpG ODN via NF-kappaB- and p38-dependent pathways in human B cells.

References

Apr 6, 1995·Nature·A M KriegD M Klinman
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·F L RockJ F Bazan
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Feb 19, 2000·Current Opinion in Immunology·A M Krieg
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D ZdilarZ M Younossi
Jun 3, 2000·Annual Review of Immunology·F SallustoA Lanzavecchia
Sep 28, 2000·Cellular Immunology·J P VasilakosM A Tomai
Dec 9, 2000·The Journal of Biological Chemistry·P LoetscherI Clark-Lewis
Jul 13, 2002·European Journal of Immunology·Parviz Ahmad-NejadHermann Wagner
Dec 24, 2002·Current Opinion in Immunology·Shizuo Akira
May 27, 2003·Nature Immunology·Ningshu LiuKevin B Bacon
Oct 31, 2003·Nature Immunology·Stanford L PengAndrea Gerth
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Meri K TulicQutayba Hamid

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Citations

Jun 1, 2013·Journal of Inflammation·Katharine E BlackMaureen R Horton
Apr 22, 2011·Expert Review of Vaccines·Christian BodeDennis M Klinman
Jun 1, 2008·Expert Opinion on Drug Discovery·Coline Ple, Catherine Duez
Mar 4, 2008·Clinical and Experimental Dermatology·K SugitaY Tokura
Jul 16, 2008·European Journal of Immunology·Makoto IshiiSteven L Kunkel
Apr 23, 2009·European Journal of Immunology·Weronika RudnickaWlodzimierz Maslinski
Oct 19, 2005·Veterinary Immunology and Immunopathology·Asmi Citra Malina A R TassakkaMasahiro Sakai
May 12, 2005·Current Opinion in Immunology·Stanford L Peng
Sep 10, 2013·The Journal of Allergy and Clinical Immunology·Christian HennigGesine Hansen
Apr 4, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sada BoodooMaureen R Horton
Dec 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michiel van GentMaaike E Ressing
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhu GuoSuryaprakash Sambhara
Sep 11, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Waleed H Mahallawi, Talal M Aljeraisi

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