Abstract
CpG oligodeoxynucleotides (CpG ODN) are known to elicit Th1 immune responses via TLR9. However, the precise mechanisms through which B cells are involved in this phenomenon are not fully understood. We investigated the effect of CpG ODN on the induction of Th1-chemoattractant CXCR3 chemokines, IP-10, Mig, and I-TAC, in B cells. Cells from the RPMI 8226 human B cell line and human peripheral B cells were stimulated with three distinct classes of CpG ODN. As a result, CXCR3 chemokines were strongly up-regulated by CpG-B and CpG-C, but only weakly by CpG-A. Though CXCR3 chemokines are known to be induced by IFNs, blocking mAbs against IFN receptors did not inhibit their induction by CpG-B. Induction of CXCR3 chemokines was blocked by two NF-kappaB inhibitors and a p38 inhibitor. These results strongly suggest that CXCR3 chemokines are directly induced by CpG ODN via NF-kappaB- and p38-dependent pathways in human B cells.
References
Jan 1, 1992·Microbiology and Immunology·S YamamotoT Tokunaga
Apr 6, 1995·Nature·A M KriegD M Klinman
Jan 31, 1998·The Journal of Experimental Medicine·R BonecchiF Sinigaglia
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·F L RockJ F Bazan
Mar 21, 1998·The Journal of Clinical Investigation·S QinC R Mackay
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Feb 19, 2000·Current Opinion in Immunology·A M Krieg
Mar 14, 2000·Immunity·A Zlotnik, O Yoshie
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D ZdilarZ M Younossi
Jun 3, 2000·Annual Review of Immunology·F SallustoA Lanzavecchia
Sep 12, 2000·Journal of Virology·O KutschE N Benveniste
Sep 28, 2000·Cellular Immunology·J P VasilakosM A Tomai
Dec 9, 2000·The Journal of Biological Chemistry·P LoetscherI Clark-Lewis
Feb 13, 2001·Cellular Immunology·S TakeshitaD M Klinman
Jul 4, 2001·Journal of Virology·V C AsensioI L Campbell
Sep 19, 2001·The Journal of Experimental Medicine·N KadowakiY J Liu
Oct 25, 2001·International Immunology·A K YiA M Krieg
Jan 19, 2002·Journal of Virology·Lee Anne TibblesDaniel A Muruve
Jul 13, 2002·European Journal of Immunology·Parviz Ahmad-NejadHermann Wagner
Dec 24, 2002·Current Opinion in Immunology·Shizuo Akira
Feb 1, 2003·Blood·Nadia L BernasconiAntonio Lanzavecchia
May 27, 2003·Nature Immunology·Ningshu LiuKevin B Bacon
May 30, 2003·Journal of Leukocyte Biology·Jason D MarshallGary Van Nest
Oct 31, 2003·Nature Immunology·Stanford L PengAndrea Gerth
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Meri K TulicQutayba Hamid
Citations
Jun 1, 2013·Journal of Inflammation·Katharine E BlackMaureen R Horton
Apr 22, 2011·Expert Review of Vaccines·Christian BodeDennis M Klinman
Jun 1, 2008·Expert Opinion on Drug Discovery·Coline Ple, Catherine Duez
Aug 8, 2007·Microbial Pathogenesis·Mette EliassonArne Egesten
Mar 4, 2008·Clinical and Experimental Dermatology·K SugitaY Tokura
Jul 16, 2008·European Journal of Immunology·Makoto IshiiSteven L Kunkel
Apr 23, 2009·European Journal of Immunology·Weronika RudnickaWlodzimierz Maslinski
Oct 19, 2005·Veterinary Immunology and Immunopathology·Asmi Citra Malina A R TassakkaMasahiro Sakai
May 12, 2005·Current Opinion in Immunology·Stanford L Peng
Sep 10, 2013·The Journal of Allergy and Clinical Immunology·Christian HennigGesine Hansen
Dec 6, 2014·Tuberculosis·Soren T HoffElse Marie Agger
Nov 3, 2005·International Immunology·Jung Mogg KimMyung-Ju Ahn
Apr 4, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sada BoodooMaureen R Horton
Dec 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michiel van GentMaaike E Ressing
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhu GuoSuryaprakash Sambhara
Sep 11, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Waleed H Mahallawi, Talal M Aljeraisi