CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts

Journal of Translational Medicine
Michelandrea De CesareNadia Zaffaroni

Abstract

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare and locally aggressive disease. DMPM prognosis is dismal, mainly due to the lack of effective treatment options and the development of new therapeutic strategies is urgently needed. In this context, novel immunotherapy approaches can be explored in an attempt to improve DMPM patients' survival. We tested the efficacy of CpG-oligodeoxynucleotides (CpG-ODN), synthetic DNA sequences recognized by Toll-like receptor 9 and able to induce innate/adaptive immune response, in two DMPM orthotopic xenografts (MesoII and STO), which properly recapitulate the dissemination pattern of the disease in the peritoneal cavity. Severe combined immunodeficiency mice carrying DMPM xenografts were treated at different stages of tumor development with i.p. delivered CpG-ODN1826 for 4 weeks. CpG-ODN1826-induced modulation in the composition of peritoneal immune infiltrate was assessed by flow cytometry. When administered to early-stage tumors (i.e., 4 days after i.p. DMPM cell injection in mice), the agent exhibited impressive efficacy against MesoII by completely inhibiting tumor take and ascites development (no evidence of tumor masses and ascites in 6/6 mice at necropsy), and also impaired ...Continue Reading

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Citations

Sep 8, 2017·Cancer Biology & Therapy·Francesca BianchiLucia Sfondrini
May 1, 2019·Current Pharmaceutical Biotechnology·Abbas H AzandaryaniTahereh Jamshidnejad-Tosaramandani
Jan 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilda D'AnnessaGiorgio Colombo
Jul 20, 2019·Journal of Immunology Research·Valentino Le NociLucia Sfondrini
Jun 8, 2021·Frontiers in Oncology·Ang LiXuemei Zhang
May 8, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Francesca ArnaboldiIsabella Barajon

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Methods Mentioned

BETA
biosensors
xenograft
PCR
xenografts
lavage
lavages
Protein Assay
flow cytometry
flow

Software Mentioned

FlowJo

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