CPPD crystal deposition disease of the cervical spine: a common cause of acute neck pain encountered in the neurology department

Journal of the Neurological Sciences
Yoshiki SekijimaShu-Ichi Ikeda

Abstract

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is one of the most common forms of crystal-associated arthropathy in the elderly. However, CPPD deposition on the cervical spine is less well known, and only a limited number of cases have been reported to date. Here, we report our recent clinical experience with CPPD crystal deposition disease of the cervical spine and describe the clinical features of this disease. Fourteen patients with clinically diagnosed CPPD crystal deposition disease of the cervical spine at our department during the period from January 2005 to December 2008 were analyzed retrospectively. Patients ranged in age from 54 to 92 (mean+/-SD, 77.5+/-8.5). Chief symptoms of patients were acute posterior neck pain and fever. All patients had markedly restricted neck rotation. Serum CRP level was highly elevated in all patients (10.16+/-5.35 mg/dL). Computed tomography of the cervical spine demonstrated linear calcific deposits in the transverse ligament of atlas (crowned dens syndrome) in all patients. Calcific deposits were also found in other periodontoid structures and the ligamenta flava in some patients. Posterior neck pain, fever, and increased serum inflammatory indicators were relieved wi...Continue Reading

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Citations

Feb 9, 2013·Clinical Rheumatology·Mitchell UhKenneth Blocka
Jun 6, 2013·Radiology·Eric Y ChangDonald L Resnick
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Hang-Korng Ea, Frédéric Lioté
Jul 9, 2013·The Spine Journal : Official Journal of the North American Spine Society·Tomohiro MoritaToshio Fukutake
Jun 29, 2013·Neuro-Chirurgie·M Godfrin-ValnetD Wendling
Aug 23, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Daniel ZweifelJoachim Obwegeser
May 21, 2014·Headache·Michele VianaPeter J Goadsby
May 27, 2015·The Spine Journal : Official Journal of the North American Spine Society·Hao ZhangErwei Sun
Aug 3, 2017·The Journal of Rheumatology·Hélène PetitEmmanuel Chatelus
Mar 30, 2019·JAMA : the Journal of the American Medical Association·Rachel CooperDimitrios Farmakiotis
Feb 15, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Dhruv M PatelMichael J Hoch
May 23, 2020·BMJ Case Reports·Hiroshi SugimotoKeisuke Sugimoto
Aug 2, 2021·Clinical Imaging·Robert M Kwee, Thomas C Kwee

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