CpsY influences Streptococcus iniae cell wall adaptations important for neutrophil intracellular survival.

Infection and Immunity
Jonathan P Allen, Melody N Neely

Abstract

The ability of a pathogen to evade neutrophil phagocytic killing mechanisms is critically important for dissemination and establishment of a systemic infection. Understanding how pathogens overcome these innate defenses is essential for the development of optimal therapeutic strategies for invasive infections. CpsY is a conserved transcriptional regulator previously identified as an important virulence determinant for systemic infection of Streptococcus iniae. While orthologs of CpsY have been associated with the regulation of methionine metabolism and uptake pathways, CpsY additionally functions in protection from neutrophil-mediated killing. S. iniae does not alter neutrophil phagosomal maturation but instead is able to adapt to the extreme bactericidal environment of a mature neutrophil phagosome, a property dependent upon CpsY. This CpsY-dependent adaptation appears to involve stabilization of the cell wall through peptidoglycan O-acetylation and repression of cellular autolysins. Furthermore, S. iniae continues to be a powerful model for investigation of bacterial adaptations during systemic streptococcal infection.

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Citations

Sep 25, 2012·Applied and Environmental Microbiology·Candice M MillardAndrew C Barnes
Jan 9, 2013·Infection and Immunity·Yoann Le BretonKevin S McIver
Mar 13, 2014·Developmental and Comparative Immunology·Hannah M RoweMelody N Neely
Feb 24, 2015·Biochimica Et Biophysica Acta·Christopher N LaRock, Victor Nizet
Sep 22, 2017·PLoS Pathogens·Stephanie A Ragland, Alison K Criss
Oct 18, 2018·Frontiers in Microbiology·David SychanthaAnthony J Clarke

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