PMID: 9161700Jan 1, 1996Paper

CR1 density polymorphism and expression on erythrocytes of patients with systemic lupus erythematosus

Autoimmunity
Emese KissGyula Szegedi

Abstract

The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomic DNA fragment of 1.8 kb separated by HindIII endonuclease digestion and agarose gel electrophoresis. Our data supported the earlier results that the number of binding sites/E for monoclonal anti-CR1 decreased among SLE patients compared with normal individuals having the same alleles for the CR1/E density. At the same time the novelty of our recent results was that the decreased expression of CR1 on E correlated significantly with kidney involvement in patients homozygous for the CR1/E high density allele (HH). These data suggest that the deficiency of the detectable number of CR1 on erythrocytes is acquired in this SLE population.

References

Jul 1, 1992·Scandinavian Journal of Immunology·R A Quadri, J A Schifferli
Apr 1, 1987·Kidney International·L A Hebert, G Cosio
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester

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Citations

Jul 2, 2003·Journal of Clinical Pathology·C C Mok, C S Lau
Sep 18, 2009·Annals of the New York Academy of Sciences·Aniko KapitanyEmese Kiss
Jul 8, 2008·Autoimmunity Reviews·Maria Kavai
Feb 11, 2015·Neurobiology of Aging·Rachid MahmoudiJacques H Cohen
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Davood RostamzadehMehdi Yousefi
Feb 26, 2014·Orvosi hetilap·György PflieglerBoglárka Brúgós

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