CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide

Microbes and Infection
Wanling PanH Tabel

Abstract

Immunoglobulin M (IgM) antibodies to the variant surface glycoproteins (VSG) of African trypanosomes are the first and predominant class of anti-trypanosomal antibodies in the infected host. They are a major factor in controlling waves of parasitemia, but not in long-term survival. The macrophage receptor(s) that enables phagocytosis of IgM anti-VSG-coated African trypanosomes is unknown. We assessed whether complement receptor CR3 (CD11b/CD18) might be involved in mediating phagocytosis of Trypanosoma congolense. We show that murine complement C3 fragments are deposited onto T. congolense when the trypanosomes are incubated with IgM anti-VSG and fresh mouse serum. In the presence of fresh mouse serum, there is significantly and markedly less phagocytosis of IgM-opsonized T. congolense by CD11b-deficient macrophages compared to phagocytosis by wild-type macrophages (78% fewer T. congolense are ingested per macrophage). Significantly less tumor necrosis factor (TNF)-alpha (38% less), but significantly more nitric oxide (NO) (63% more) are released by CD11b-deficient macrophages that have engulfed trypanosomes than by equally treated wild-type macrophages. We conclude that CR3 is the major, but not the only, receptor involved in ...Continue Reading

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May 6, 2010·Parasitology·Stefan MagezMagdalena Radwanska
Oct 20, 2011·The Journal of Parasitology·Ayoola Oladiran, Miodrag Belosevic
Oct 15, 2009·Future Microbiology·Stefan Magez, Magdalena Radwanska
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Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guojian Wei, Henry Tabel
Jun 25, 2015·Microbiology Spectrum·Donald N Forthal

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