Cracking the Glycome Encoder: Signaling, Trafficking, and Glycosylation

Trends in Cell Biology
Frederic A Bard, Joanne Chia

Abstract

The glycoproteome, the ensemble of glycans and their carrier proteins, plays major roles in multicellular life by regulating cell interactions with their environment. How information is encoded into the glycome, in other words how glycosylation is modulated in response to signals, remains largely unclear. Glycosylation enzymes operate predominantly in the endoplasmic reticulum (ER) and Golgi, a highly compartmentalized membrane-bound environment. Recent work indicates that this compartmentalization is plastic and tightly regulated. For instance, specific signals can induce the relocation of O-glycosylation enzymes, GALNTs, from the Golgi to the ER, resulting in significant upregulation of O-glycosylation initiation. We have named this re-compartmentation process the 'GALA pathway'. GALA illustrates how membrane trafficking in the secretory pathway can regulate protein glycosylation and thus encode information in the glycome.

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Mar 13, 2016·Biochimica Et Biophysica Acta·Joanne ChiaFrederic Bard
Aug 3, 2016·The Journal of Cell Biology·Shawn Jordan
May 31, 2017·Angewandte Chemie·Jingjing HuiHuangxian Ju
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Jan 27, 2021·Glycobiology·Anabela M CutineGabriel A Rabinovich
Aug 22, 2020·Journal of Chromatography. a·Shuyue WangMingliang Ye
Apr 6, 2017·Developmental Biology·Angelica Aguilera-Gomez, Catherine Rabouille
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Xiaoyan Zhang
Jul 3, 2021·Nature Communications·Rebecca NasonYoshiki Narimatsu
Sep 23, 2021·Immunopharmacology and Immunotoxicology·Dongkui XuTao Gu

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