Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages

Journal of Applied Microbiology
M Feldman, Daniel Grenier

Abstract

Periodontitis is an inflammatory disease of polymicrobial origin that affects the tooth-supporting tissues. With the spread of antibiotic resistance among pathogenic bacteria, alternative strategies are required to better control infectious diseases such as periodontitis. The aim of our study was to investigate whether two natural compounds, A-type cranberry proanthocyanidins (AC-PACs) and licochalcone A, act in synergy against Porphyromonas gingivalis and the host inflammatory response of a macrophage model. Using a checkerboard microtitre test, AC-PACs and licochalcone A were found to act in synergy to inhibit P. gingivalis growth and biofilm formation. Fluorescein isothiocyanate-labelled P. gingivalis adhesion to oral epithelial cells was also inhibited by a combination of the two natural compounds in a synergistic manner. Fluorometric assays showed that although AC-PACs and licochalcone A reduced both MMP-9 and P. gingivalis collagenase activities, no synergy was obtained with a combination of the compounds. Lastly, AC-PACs and licochalcone A also acted in synergy to reduce the lipopolysaccharide (LPS)-induced secretion of the pro-inflammatory mediators IL-1β, TNF-α, IL-6 and IL-8 in a macrophage model. A-type cranberry pro...Continue Reading

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Citations

Nov 5, 2013·European Journal of Pharmacology·Iro PalaskaTheoharis C Theoharides
Sep 11, 2013·International Journal of Biometeorology·Elizabeth R EllwoodRichard B Primack
Jun 21, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M N M NogueiraD M P Spolidorio
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May 26, 2016·Molecular Medicine Reports·Xinhui YangQiusheng Zheng
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meenakshi RajendiranLin Chen
Jun 15, 2021·RSC Medicinal Chemistry·Kaitlind C HowardSylvie Garneau-Tsodikova

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