Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet

European Journal of Nutrition
Thamara C PeixotoP C Lisboa

Abstract

Obese individuals have higher production of reactive oxygen species, which leads to oxidative damage. We hypothesize that cranberry extract (CE) can improve this dysfunction in HFD-induced obesity in rats since it has an important antioxidant activity. Here, we evaluated the effects of CE in food intake, adiposity, biochemical and hormonal parameters, lipogenic and adipogenic factors, hepatic morphology and oxidative balance in a HFD model. At postnatal day 120 (PN120), male Wistar rats were assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44.5% (35.2% from lard) energy from fat. At PN150, 12 animals from SD and HFD groups were killed while the others were subdivided into four groups (n = 12/group): animals that received 200 mg/kg cranberry extract (SD CE, HFD CE) gavage/daily/30 days or water (SD, HFD). At PN180, animals were killed. HFD group showed higher body mass and visceral fat, hypercorticosteronemia, higher liver glucocorticoid sensitivity, cholesterol and triglyceride contents and microsteatosis. Also, HFD group had higher lipid peroxidation (plasma and tissues) and higher protein carbonylation (liver and adipose tissue) compared to SD group. HFD CE gr...Continue Reading

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Citations

May 30, 2019·Food & Function·Livia de Almeida AlvarengaDenise Mafra
May 30, 2020·Foods·Bhagavathi Sundaram SivamaruthiChaiyavat Chaiyasut
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christina M Coleman, Daneel Ferreira
Oct 12, 2018·International Journal of Molecular Sciences·Patricia Novaes SoaresPatricia Cristina Lisboa
Sep 22, 2019·International Journal of Molecular Sciences·Hanna Zielinska-BlizniewskaRadoslaw Zajdel
Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Seul-Ki KimWon-Ki Kim
Aug 18, 2021·Food Research International·Haitao JiangWeibo Jiang
Nov 21, 2021·BMC Complementary Medicine and Therapies·Kourosh Masnadi ShiraziZeinab Nikniaz

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