Cranial computed tomographic findings in tuberous sclerosis are not affected by sex

Developmental Medicine and Child Neurology
A ClarkeJ P Osborne

Abstract

Males with the tuberous sclerosis complex (TSC) have been shown to be more at risk of learning disorder than females. A retrospective population based study was undertaken to see if males with TSC have more cerebral lesions than females. 47 of 131 individuals with TSC identified in a prevalence study had a cranial CT scan available for review. No significant difference between the sexes was found in the number of subependymal nodules or the number, site or size of parenchymal lesions. However, males with five or fewer parenchymal lesions were at greater risk of learning disorder than females. The increased risk of learning disorder in males with tuberous sclerosis is not accounted for by an increase in number, site or size of cranial lesions as seen on CT scans. Therefore there must be an alternative mechanism to account for this difference between the sexes.

References

Nov 1, 1992·The Journal of Dermatology·O W Houser, M R Gomez
Sep 1, 1992·Developmental Medicine and Child Neurology·C W Shepherd, J B Stephenson
Dec 1, 1991·Archives of Disease in Childhood·D W WebbJ P Osborne
Jun 1, 1991·Journal of Medical Genetics·D W WebbJ P Osborne
Jan 1, 1991·Annals of the New York Academy of Sciences·J P OsborneD Webb
Jan 1, 1991·Annals of the New York Academy of Sciences·P CuratoloO Dulac
Mar 1, 1987·Archives of Neurology·E S RoachD W Laster
Dec 1, 1969·Journal of Neurology, Neurosurgery, and Psychiatry·S Bundey, K Evans
May 1, 1994·Annals of Human Genetics·S PoveyE B Robson

❮ Previous
Next ❯

Citations

Oct 8, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·J E Harrison, P F Bolton
Feb 3, 2007·European Child & Adolescent Psychiatry·Petrus J de VriesPatrick F Bolton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M E A P M AdriaensenM Prokop
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
J SaadaA Benachi
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Caterina MichelozziGianpaolo Cornalba
© 2021 Meta ULC. All rights reserved