Cranial irradiation increases tumor growth in experimental breast cancer brain metastasis

NMR in Biomedicine
Amanda M HamiltonPaula J Foster

Abstract

Whole-brain radiotherapy is the standard of care for patients with breast cancer with multiple brain metastases and, although this treatment has been essential in the management of existing brain tumors, there are many known negative consequences associated with the irradiation of normal brain tissue. In our study, we used in vivo magnetic resonance imaging analysis to investigate the influence of radiotherapy-induced damage of healthy brain on the arrest and growth of metastatic breast cancer cells in a mouse model of breast cancer brain metastasis. We observed that irradiated, but otherwise healthy, neural tissue had an increased propensity to support metastatic growth compared with never-irradiated controls. The elucidation of the impact of irradiation on normal neural tissue could have implications in clinical patient management, particularly in patients with residual systemic disease or with residual radio-resistant brain cancer.

References

Mar 1, 1979·Pharmacological Research Communications·A QuintanaA Bonaccorsi
Jul 6, 1988·Journal of the National Cancer Institute·P BasseM Hokland
Jun 21, 2001·Journal of Neurosurgery·C Wild-BodeW Wick
Mar 19, 2005·Carcinogenesis·Caridad RosetteMikhail F Denissenko
Aug 6, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W J SpeakeS A Watson
Oct 10, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chris HeynPaula J Foster
May 6, 2008·The Breast : Official Journal of the European Society of Mastology·R Stuart-HarrisP Pharoah
Sep 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul R LockmanQuentin R Smith
Dec 7, 2011·Contrast Media & Molecular Imaging·C McFaddenP J Foster
May 12, 2012·International Journal of Radiation Biology·Guillaume DesmaraisBenoit Paquette
Sep 13, 2012·Breast Cancer Research and Treatment·Nils D ArvoldBrian M Alexander
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicholas H VarvelMathias Jucker
Jan 17, 2013·Clinical & Experimental Metastasis·Inderjit DaphuFrits Thorsen
Dec 7, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Donna H MurrellAnn F Chambers
Jun 21, 2014·Journal of the National Cancer Institute·Stephan WoditschkaPatricia S Steeg
Feb 19, 2015·Glia·Matthew D LiTheo D Palmer
Apr 15, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Amanda M HamiltonBrian K Rutt
Apr 29, 2015·International Journal of Radiation Biology·Guillaume DesmaraisBenoit Paquette
Sep 1, 2015·Clinical & Experimental Metastasis·DeeDee SmartPatricia S Steeg
Apr 27, 2017·Frontiers in Pharmacology·Kaci A BohnPaul R Lockman

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Citations

Jul 10, 2020·Cancer Research·Manuel ValienteFrank Winkler
Aug 29, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kierstin P MeloPaula J Foster

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