Cranial irradiation regulates CREB-BDNF signaling and variant BDNF transcript levels in the mouse hippocampus

Neurobiology of Learning and Memory
Yeonghoon SonChangjong Moon

Abstract

The brain can be exposed to ionizing radiation in various ways, and such irradiation can trigger adverse effects, particularly on learning and memory. However, the precise mechanisms of cognitive impairments induced by cranial irradiation remain unknown. In the hippocampus, brain-derived neurotrophic factor (BDNF) plays roles in neurogenesis, neuronal survival, neuronal differentiation, and synaptic plasticity. The significance of BDNF transcript variants in these contexts is becoming clearer. In the present study, both object recognition memory and contextual fear conditioning task performance in adult C57BL/6 mice were assessed 1 month after a single exposure to cranial irradiation (10 Gy) to evaluate hippocampus-related behavioral dysfunction following such irradiation. Furthermore, changes in the levels of BDNF, the cAMP-response element binding protein (CREB) phosphorylation, and BDNF transcript variants were measured in the hippocampus 1 month after cranial irradiation. On object recognition memory and contextual fear conditioning tasks, mice evaluated 1 month after irradiation exhibited significant memory deficits compared to sham-irradiated controls, but no apparent change was evident in locomotor activity. Both phospho...Continue Reading

References

Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Sep 1, 2001·Cellular and Molecular Life Sciences : CMLS·A K McAllister
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·A E WestM E Greenberg
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amelia A Russo-NeustadtMichael J Chen
Nov 19, 2004·The European Journal of Neuroscience·Shoshanna VaynmanFernando Gomez-Pinilla
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Dec 7, 2006·Journal of Neuroscience Research·Tamara AidTõnis Timmusk
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amrita NairVidita A Vaidya
Oct 9, 2007·Molecular and Cellular Neurosciences·C ChiaruttiniE Tongiorgi
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Matthew K SchindlerDavid R Riddle
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farah D LubinJ David Sweatt
Mar 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle A SimmonsGary Lynch
Dec 9, 2009·Pharmacology, Biochemistry, and Behavior·Heung-Sik SeoChangjong Moon
Apr 5, 2011·Biochemical Pharmacology·Miyoung YangChangjong Moon
Feb 10, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gabriele BajEnrico Tongiorgi
Mar 23, 2012·Journal of Veterinary Science·Miyoung YangChangjong Moon
Feb 12, 2014·Brain, Behavior, and Immunity·Miyoung YangChangjong Moon
Aug 16, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jinwook KimChangjong Moon
Jan 18, 2015·Brain, Behavior, and Immunity·Yeonghoon SonChangjong Moon

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Citations

Sep 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jinwook KimChangjong Moon
Dec 23, 2015·Neural Regeneration Research·Miyoung Yang, Changjong Moon
Apr 21, 2018·International Journal of Molecular Sciences·Jacob RaberAmy Kronenberg
Jun 14, 2020·International Journal of Molecular Sciences·Mary Jasmin AngChangjong Moon
Jul 30, 2019·Frontiers in Neuroscience·Judith MetzdorfIngo Kleiter
May 16, 2019·Neural Regeneration Research·Hae June LeeJoong Sun Kim

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