PMID: 8585490Nov 1, 1995Paper

Cranial MR in Wilson disease: abnormal white matter in extrapyramidal and pyramidal tracts.

AJNR. American Journal of Neuroradiology
H N Van Wassenaer-van HallW P Mali

Abstract

To describe abnormal white matter in the brain on MR in Wilson disease and to compare with anatomic location of white matter tracts. Forty-six patients with Wilson disease were examined. Axial T1-weighted inversion-recovery, axial T2-weighted spin-echo, and coronal T2*-weighted gradient-echo MR images were performed. Imaging studies were compared with clinical data. Seventeen patients showed abnormalities in the region coinciding with the following white matter tracts: corticospinal tract (24%, n = 11), dentatorubrothalamic tract (24%, n = 11), and pontocerebellar tract (17%, n = 8). Abnormal extrapyramidal and pyramidal white matter tracts are part of the neuroimaging spectrum of Wilson disease. No significant correlation was found with neurologic groups and individual white matter tracts affected.

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