Cranial nerve involvement in patients with MOG antibody-associated disease

Neurology. Neuroimmunology and Neuroinflammation
Alvaro Cobo-CalvoRomain Marignier

Abstract

To describe clinical and radiologic features of cranial nerve (CN) involvement in patients with myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) and to assess the potential underlying mechanism of CN involvement using a nonhuman primate (NHP) model. Epidemiologic, clinical, and radiologic features from a national cohort of 273 MOG-IgG-positive patients were retrospectively reviewed for CN involvement between January 2014 and January 2018. MOG-IgG binding was evaluated in CNS, CN, and peripheral nerve tissues from NHP. We identified 3 MOG-IgG-positive patients with radiologic and/or clinical CN involvement. Two patients displayed either trigeminal or vestibulocochlear nerve lesions at the root level, and the remaining patient had an oculomotor nerve involvement at the root exit and at the cisternal level. Additional CNS involvement was found in all 3 patients. None of the 3 patients' sera recognized MOG expression in CN of NHP. Craneal nerve involvement can coexist in patients with MOG antibody disease, although the underlying pathophysiology remains elusive.

References

Jun 14, 2001·Journal of Clinical Immunology·H C von BüdingenC P Genain
Apr 9, 2002·Multiple Sclerosis : Clinical and Laboratory Research·A H C van der MeijsF Barkhof
Jun 17, 2005·Multiple Sclerosis : Clinical and Laboratory Research·C J da SilvaC P Tilbery
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Cecilia B MartaNancy H Ruddle
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·A PichiecchioS Bastianello
Oct 12, 2012·Neurology·Yoshiki TakaiMasashi Aoki
May 10, 2013·Neurology·Romain MarignierUNKNOWN NOMADMUS Study Group
Sep 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie C MayerEdgar Meinl
Oct 12, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A B LaemmerA Schramm
Jan 15, 2014·Neurology·Douglas Kazutoshi SatoKazuo Fujihara
Oct 26, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Romana HöftbergerAlbert Saiz
Nov 22, 2014·Journal of Clinical Neuromuscular Disease·Prompan Mingbunjerdsuk, Bashar Katirji
Nov 21, 2015·Neurology. Neuroimmunology and Neuroinflammation·Franziska Di PauliThomas Berger
Jan 21, 2017·Neurology. Neuroimmunology and Neuroinflammation·Ryo OgawaKazuo Fujihara
Feb 12, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Natalia ShorAnne Bertrand
Jun 7, 2017·Veterinary Pathology·Lev StimmerChé Serguera
Aug 5, 2017·Journal of Neurology·Álvaro Cobo-CalvoRomain Marignier
Nov 15, 2017·Brain : a Journal of Neurology·Maciej JurynczykJacqueline Palace
Nov 17, 2017·Multiple Sclerosis and Related Disorders·Seungyeon KimKiyeun Nam
Nov 18, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Bonnan, P Cabre
Apr 27, 2018·Neurology·Alvaro Cobo-CalvoUNKNOWN OFSEP and NOMADMUS Study Group

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Citations

Dec 14, 2019·Neurology. Neuroimmunology and Neuroinflammation·Josep DalmauScott S Zamvil
Oct 16, 2019·Neurology. Neuroimmunology and Neuroinflammation·Stephan WinklmeierEdgar Meinl
Apr 2, 2020·Expert Opinion on Biological Therapy·Ankelien DuchowJudith Bellmann-Strobl
Feb 15, 2019·Current Opinion in Neurology·Alvaro Cobo-CalvoRomain Marignier
Oct 9, 2020·Therapeutic Advances in Neurological Disorders·Harald Hegen, Markus Reindl
Nov 22, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Jia LiuSatoshi Kuwabara
Dec 5, 2020·Journal of the Neurological Sciences·Shabeer PaulImtiyaz Ahmad Bhat
Dec 11, 2020·Multiple Sclerosis and Related Disorders·Tomoaki Shima, Akira Tsujino
Oct 14, 2020·Revue neurologique·N ShorUNKNOWN NOMADMUS study group
Jan 11, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Susanna AsseyerUNKNOWN Neuromyelitis Optica Study Group
Dec 30, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Samantha A BanksEoin P Flanagan
Aug 7, 2020·AJR. American Journal of Roentgenology·Mona ShahriariDavid M Yousem
Nov 10, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Arlette L BruijstensK Rostasy
Mar 26, 2021·Der Nervenarzt·Frederike C OertelFriedemann Paul
Jun 17, 2020·Survey of Ophthalmology·Lakshmi LeishangthemJohn Chen
Jun 23, 2019·Journal of Neuroradiology. Journal De Neuroradiologie·Marc DenèveFabrice Bonneville
Jun 8, 2021·Acta neurologica Belgica·Solène DaubyEmilie Lommers
Jun 22, 2021·Clinical and Experimental Immunology·Frederik BartelsClaudia Chien
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Zhiyong ChenJing Liang Loo
Apr 22, 2020·Revue neurologique·X AyrignacP Labauge

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Methods Mentioned

BETA
flow cytometry
confocal microscopy
PCR

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