Abstract
The morbidity and mortality of herpes simplex encephalitis have decreased since the 1980s with the use of antivirals, but have remained stable in the last couple of years. One cause of morbidity is the development of focal hemorrhagic necrosis and edema in the temporal lobe, giving rise to space-occupying lesions, with a subsequent elevation of intracranial pressure. In some cases, the necrosis and edema can be refractory to medical treatment, with fatal outcome. Under these circumstances, some authors proposed decompressive craniectomy to treat severe intracranial hypertension and prevent serious neurologic deficits. We report the clinical outcomes of 2 adolescents affected with herpes simplex encephalitis who developed, during the course of their illness, severe intracranial hypertension refractory to medical treatment. Decompressive surgery was undertaken, with good outcomes in both patients.
References
Sep 20, 1992·The New England Journal of Medicine·R J Whitley, J W Gnann
Feb 1, 1997·Neurology·S SchwabW Hacke
May 7, 1999·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H EbelN Klug
Aug 21, 2001·Intensive Care Medicine·E TafernerE Schmutzhard
Oct 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S KameiK Hirayanagi
Feb 3, 2007·Pediatrics·Jorina M ElbersDaune MacGregor
Sep 4, 2007·Pediatric Neurology·Banan MusallamDiana Averbuch
Jan 5, 2008·Journal of Neurosurgery·Matthew A Adamo, Eric M Deshaies
Citations
Sep 22, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ha Son NguyenAaron A Cohen-Gadol
Sep 29, 2011·Neurosurgery·Erdem GüresirHartmut Vatter
Jan 25, 2013·Emerging Infectious Diseases·Michael A SilvermanAsim A Ahmed
Jul 16, 2013·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·S Honeybul, K M Ho
May 1, 2012·Acta neurochirurgica·Jordi Pérez-BovetSecundino Martín-Ferrer
May 15, 2013·Brain Injury : [BI]·S Honeybul, K M Ho
Jul 9, 2013·Critical Care Clinics·Andreas H Kramer
Nov 6, 2012·Neuroimaging Clinics of North America·Jason A Heth
Sep 22, 2015·Critical Care : the Official Journal of the Critical Care Forum·Youenn JouanAntoine Guillon
Jun 3, 2015·Neurocritical Care·David B KurlandJ Marc Simard
Jan 17, 2017·Internal Medicine·Yukinori Harada, Yuuta Hara
Aug 27, 2014·Journal of Child Neurology·Pratibha SinghiAshish Aggarwal
Mar 19, 2020·British Journal of Neurosurgery·Vijai WilliamsKarthi Nallasamy
Jun 13, 2013·Neurosurgery·Stephen HoneybulKwok Ho
Feb 23, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Jan MračekVladimir Priban