PMID: 8339759Jun 1, 1993Paper

Craniofacial patterning in Klinefelter (47 XXY) adults

European Journal of Orthodontics
T BrownG C Townsend

Abstract

Radiographic cephalometry incorporating a pattern profile analysis was used to compare 26 adult Klinefelter males from Finland with first degree adult relatives, 15 males and 14 females. Compared with female relatives, the 47 XXY males were larger in almost all craniofacial linear dimensions, but were similar in facial shape apart from greater mandibular prognathism. Mandibular dimensions in particular differed between the Klinefelter and unaffected males, the corpus length being larger, the ramus shorter and the gonial angle more obtuse in the 47 XXY group. The prominent facial profile, most marked in the mandible, was a dominant feature of the Klinefelter subjects who also displayed a more acute median cranial base angle than each control group. Generally, Klinefelter morphology was marked by greater variability or patterning of the craniofacial structures compared with relatives, possibly due to decreased developmental canalization. It is proposed that the 47 XXY complex may affect endochondral growth in the cranial base, as well as having a direct influence on jaw growth.

Citations

May 8, 2000·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·R S Nanda
Apr 26, 2012·European Journal of Orthodontics·Sara RizellHeidrun Kjellberg
Aug 31, 2014·Atlas of the Oral and Maxillofacial Surgery Clinics of North America·Rita Shiang
Mar 21, 2007·Archives of Oral Biology·Raija Lähdesmäki, Lassi Alvesalo
Feb 11, 2000·Archives of Oral Biology·M GrönL Alvesalo
Jul 29, 2008·Archives of Oral Biology·Lassi Alvesalo
Jan 30, 2016·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Rebecca J Bird, Bradley J Hurren
Aug 15, 2001·American Journal of Medical Genetics·D J ShanerJ S Bamforth
Oct 7, 2004·Plastic and Reconstructive Surgery·Sarper YilmazAli Riza Erçöçen
Oct 17, 1998·Australian Dental Journal·G C TownsendP M Bartold
Sep 17, 2010·Expert Review of Molecular Diagnostics·Jacques C Giltay, Merel C Maiburg

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