Craniopharyngiomas in children - experience of consecutive 152 operated cases

Acta Endocrinologica : the International Journal of the Romanian Society of Endocrinology
A V CiureaC Toader

Abstract

Craniopharyngiomas (CPH) are benign tumors, rarely encountered in children, representing 5-6% of all intracranial tumors. This study aimed to analyze the surgical management and quality of life in a series of CPH pediatric cases. This was a multicenter study performed over a 25-year period (1994 - 2019) in Bucharest. 152 children (0-17 years old) were treated for CPH. Preoperative manifestations were intracranial hypertension, endocrine dysfunction, visual impairment, ataxia, intellectual performance decrease. Considering all surgical approaches used, we advocate for pterional approach to best fit in CPH. We achieved gross-total removal (GTR) in 83 cases (54.4%), near-total resection (NTR) in 13 cases (9%), partial resection (PTR) in 51 cases (33.3%). 5 cases were biopsies (3.2%). Gamma Knife Surgery was performed in 10 cases (6.5%), all recurrences. At 6 months GOS revealed: Good Recovery 70 cases (46.2%), Moderate Disability 62 cases (40.7%), Severe Disability 13 (8.5%), Vegetative State 2 cases (1.3%), Deceased 5 cases (3.2%). Complications were: diabetes insipidus (89.3%); hypopituitarism (66.4%); hypothalamic damage (17.7%); visual deterioration (18.4%). Surgery remains the main option, but GTR complications prove the nece...Continue Reading

Citations

Feb 25, 2021·International Medical Case Reports Journal·Nguyen Duy HungNguyen Minh Duc

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