Craving Moderates the Effects of Intranasal Oxytocin on Anger in Response to Social Stress Among Veterans With Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder.

Journal of Clinical Psychopharmacology
Alexander J MelkonianSudie E Back

Abstract

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur among US military veterans. Oxytocin may have therapeutic value in treating both conditions. The potential for oxytocin to augment affective features common to PTSD and AUD, such as anger, is relevant to inform emerging treatments. We examined the influence of intranasally administered oxytocin on connections between alcohol craving and stress-induced anger in a sample of 73 veterans (91.3% men) with co-occurring PTSD and AUD. Participants self-administered oxytocin (40 IU) or placebo (saline) 45 minutes before completing the Trier Social Stress Task (TSST). Self-reports of alcohol craving and anger were assessed pre- and post-TSST using a modified visual analog scale. Multiple regression analysis, including main effects for group, baseline craving, and their interaction, was used to predict post-TSST anger. A marginally significant interaction was observed, suggesting a positive association between baseline craving and anger for those in the oxytocin group (B = 0.65, P = 0.01). Among those reporting low craving, participants in the oxytocin group reported significantly lower post-TSST anger than those in the placebo group. The current study i...Continue Reading

References

Feb 23, 2010·Behavior Therapy·Bunmi O OlatunjiDavid F Tolin
Dec 27, 2011·Hormones and Behavior·Iain S McGregor, Michael T Bowen
May 11, 2012·The American Journal of Drug and Alcohol Abuse·H G RoozenI H A Franken
Oct 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Beth L MahMarian J Bakermans-Kranenburg
Apr 9, 2013·Psychopharmacology·Aimee L McRae-ClarkKathleen T Brady
Mar 25, 2014·Human Brain Mapping·Monika EcksteinRené Hurlemann
Jul 22, 2014·Psychological Trauma : Theory, Research, Practice and Policy·Tara E GalovskiPatricia A Resick
Sep 1, 2015·Biological Psychiatry·Simone G Shamay-Tsoory, Ahmad Abu-Akel
Feb 11, 2016·Hormones and Behavior·R Ne'emanS G Shamay-Tsoory
Jan 20, 2017·Alcoholism, Clinical and Experimental Research·Ismene L Petrakis, Tracy L Simpson
Jun 21, 2017·Biological Psychiatry·Franny B SpenglerRené Hurlemann
Aug 17, 2017·Current Opinion in Psychology·Casey T TaftChristopher M Murphy
May 5, 2018·Psychoneuroendocrinology·Michaela PfundmairLisa Feldmann
Aug 26, 2018·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Chelsea RomneyJulianne Holt-Lunstad
Nov 2, 2018·Experimental and Clinical Psychopharmacology·Julianne C FlanaganSudie E Back
Apr 14, 2019·Psychoneuroendocrinology·Youri R BerendsHjalmar J C van Marle
Nov 17, 2019·Journal of Clinical Psychology·Shannon R MilesUNKNOWN STRONG STAR Consortium

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