PMID: 9173066Feb 1, 1997Paper

Cream PUVA photochemotherapy

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
H StegeJ Krutmann

Abstract

Bath-PUVA-photochemotherapy lacks systemic side effects and requires low cumulative UVA doses, but a major disadvantage is the logistical requirement for bath tubs in a practice. We have developed an alternative form of topical PUVA therapy using a lipophilic emulsion vehicle for the photosensitizer 8-MOP (cream-PUVA-photochemo-therapy). A 0.0006% 8-MOP containing water-in-oil emulsion (30% H2O) was optimal for inducing photosensitivity in treated skin areas without increasing 8-MOP plasma levels. Increased skin photosensitivity was maximal 1 hour after cream application and persisted for 3 hours. We next assessed the effectiveness of cream-PUVA-photochemotherapy in the treatment of patients with chronic recalcitrant palmoplantar eczema (n = 10). In seven patients complete, and in two patients partial, remissions were observed after 40 treatments. Thus, cream-PUVA-photochemotherapy, which is easier to perform than bath-PUVA-photochemotherapy, is an effective, safe and low-cost modality, which may prove to become the topical PUVA therapy of choice for dermatological practitioners.

Citations

May 16, 2000·The British Journal of Dermatology·M Grundmann-KollmannM Podda
Dec 21, 2000·Clinical and Experimental Dermatology·J Krutmann
Nov 26, 2002·British Journal of Clinical Pharmacology·Marcella Grundmann-KollmannIrmgard Tegeder
Apr 11, 2006·Skinmed·Grazyna Broniarczyk-DylaMagdalena Prusinska-Bratos
Nov 10, 2006·The Journal of Dermatological Treatment·Kassem RiadTrau Henri
Aug 21, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H Stege
Jan 6, 2012·Journal of Allergy·Sonja Alexandra Grundmann, Stefan Beissert
Jan 29, 2000·The British Journal of Dermatology·S M HalpernL E Rhodes
Aug 12, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas HerzingerMichael Weichenthal
Aug 12, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas HerzingerMichael Weichenthal
May 13, 1999·Photodermatology, Photoimmunology & Photomedicine·M Grundmann-KollmannM Kerscher
Jun 3, 1999·The British Journal of Dermatology·M Grundmann-KollmannM Kerscher
Nov 19, 2004·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Grundmann-Kollman, A Tanew
May 4, 2005·The International Journal of Lower Extremity Wounds·Erich Köstler, Uwe Wollina
Jan 31, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·T Pozo-RománM Núñez-Cabezón
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Engin Sezer, Ilker Etikan
Apr 30, 2015·American Journal of Clinical Dermatology·Dimitar AntonovPeter Elsner
May 22, 2001·The British Journal of Dermatology·M Grundmann-KollmannM Podda
Mar 9, 2005·Photodermatology, Photoimmunology & Photomedicine·Ralf SchienerMartina Kerscher
Jan 5, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H StegeC Hünefeld

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