PMID: 3214119Jul 1, 1988Paper

Creatine determinations as an early marker for the diagnosis of acute myocardial infarction

Annals of Clinical Biochemistry
J DelangheR Wieme

Abstract

In the acute phase of acute myocardial infarction (3-8 h after onset of symptoms) an early transient increase in the creatine concentration of serum, saliva, and especially of urine can be observed. Due to the renal threshold, urine values give a much better discrimination between infarction patients and controls than do serum determination. In some patients secondary peaks of serum and urine creatine concentrations can be seen about 24-36 h after hospital admission. Intramuscular injections of 5.0 mL of a saline solution and muscular trauma interfere with the test, but with angina pectoris interference is absent or limited. Creatine leakage from myocardium is insufficient to explain the observed creatinuria in infarctions, and intact extra-cardiac tissues are believed to be involved in creatine release.

References

Nov 1, 1975·Circulation·R RobertsB E Sobel
Jun 1, 1986·Atherosclerosis·J DelangheJ Robbrecht
May 1, 1986·Annals of Clinical Biochemistry·P D Griffiths
Apr 10, 1986·The New England Journal of Medicine·T F Dolan
Jul 31, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Suzuki, M Yoshida
Jun 1, 1984·The Journal of Trauma·C J ThrelfallH B Stoner

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Citations

Jan 14, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·J R DelangheG G Leroux-Roels
Sep 1, 1994·The American Journal of the Medical Sciences·G Perez LasalaA K Markov
Jan 1, 1991·Annals of Clinical Biochemistry·J R DelangheD L Clement

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