Creatine kinase activity in human spermatozoa and seminal plasma lacks predictive value for male fertility in in vitro fertilization

Fertility and Sterility
C RolfE Nieschlag

Abstract

To examine the predictive value of creatine kinase in human spermatozoa and seminal plasma from patients treated in an IVF program. Prospective, blind clinical study. Male infertility clinic. Seventy-three patients and 32 fathers (age, <45 years). Determination of creatine kinase activity in seminal plasma, washed spermatozoa, and swim-up purified spermatozoa from patients treated in an IVF program. Creatine kinase activity in seminal plasma, washed spermatozoa, and swim-up purified spermatozoa. Creatine kinase activity in washed spermatozoa correlated significantly with normal sperm morphology. No significant correlations were found between creatine kinase activity or creatine kinase isoenzyme ratio in seminal plasma, washed spermatozoa, or swim-up purified spermatozoa and success in the IVF program. The percentage of spermatozoa with normal morphology was significantly lower in patients whose sperm did not fertilize than in patients whose sperm did fertilize oocytes and in the control group of proven fathers. Total creatine kinase activity and creatine kinase isoenzyme distribution are not sperm function markers for prediction of male fertility in IVF treatment.

References

May 1, 1983·Journal of Reproduction and Fertility·J P Kavanagh, C Darby
Aug 1, 1981·International Journal of Andrology·P P AsseoD G Ikkos
Oct 1, 1981·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·J BohnerM Eggstein

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Citations

Aug 20, 2010·Journal of Assisted Reproduction and Genetics·Maw-Sheng LeeEn-Hui Cheng
Dec 12, 2001·International Journal of Andrology·A ForceD Boucher
May 2, 2002·Molecular Reproduction and Development·Eva AxnérRebecca E Spindler
Nov 6, 2015·BioMed Research International·Rui-Xiang FengNian-Qing Lü
Sep 28, 2001·Journal of Dairy Science·A G Braundmeier, D J Miller
Nov 4, 2020·The FEBS Journal·Pablo S VillarJuan Bacigalupo

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