Creatine kinase and creatine kinase-MB release after nontraumatic cardiac arrest

The American Journal of Cardiology
M MüllnerA N Laggner

Abstract

The aim of the study was to describe the course of serum creatine kinase (CK) and its MB fraction (CK-MB) in patients surviving cardiac arrest, and to identify factors influencing CK and CK-MB release. The study was set in the community of Vienna, Austria. Data concerning cardiopulmonary resuscitation, collected within a period of 33 months, were evaluated retrospectively and compared with laboratory blood investigations collected prospectively (on admission and after 6, 12, and 24 hours) in 107 adult patients surviving a witnessed cardiac arrest for 24 hours. CK and CK-MB were elevated in >75% of the patients within 24 hours. Release of CK and CK-MB was mainly associated with electrocardiographic evidence of acute myocardial infarction (AMI) cumulative energy administered during defibrillation, and duration of chest trauma by compression. The CK-MB/CK ratio was elevated in 32% of the patients. Of patients with electrocardiographic evidence of AMI, only 49% had an elevated CK-MB/CK ratio. In conclusion, the elevation in serum CK and CK-MB fraction in patients after nontraumatic cardiac arrest is a frequent finding, and is associated with ischemic myocardial injury, as well as physical trauma to the chest. This should be conside...Continue Reading

References

Jan 9, 1978·JAMA : the Journal of the American Medical Association·J A ReiffelE B Leahey
Feb 1, 1979·The American Journal of Cardiology·P W DohertyD C Harrison
Jan 1, 1976·The American Journal of Cardiology·A EhsaniB E Sobel
Mar 15, 1991·Annals of Internal Medicine·M AkhtarP J Troup
Aug 1, 1990·European Heart Journal·J JakobssonR Nordlander
Dec 1, 1982·Clinical Biochemistry·J E Devine, L A Spatz
Jan 1, 1981·Scandinavian Journal of Thoracic and Cardiovascular Surgery·R Bendz, S Ström
May 1, 1980·British Heart Journal·L LjungdahlS Hofvendahl
Jan 1, 1993·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·U HakeH Oelert
Oct 26, 2010·Circulation. Heart Failure·Karl D PendergrassMichael E Davis

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Citations

Dec 14, 2012·Expert Review of Clinical Pharmacology·Sabino ScollettaFabio Silvio Taccone

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