PMID: 8444416Mar 1, 1993Paper

Creatine kinase-BB: a marker of liver sinusoidal damage in ischemia-reperfusion

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M VaubourdolleJ Giboudeau

Abstract

Cell damage within the sinusoidal lining of human liver grafts during transplantation is an early event that is critical in ischemia-reperfusion injury and probably plays a key role in primary liver dysfunction after transplantation. No simple biochemical marker for sinusoidal injury is currently available. Because creatine kinase activity has been described in heart endothelial cells, we hypothesized that release of this enzyme might serve as an index of sinusoidal injury. To test this hypothesis, we used several in vivo and in vitro experimental models. Occlusion of the rat hepatic pedicle in situ for 60 min (normothermic ischemia) induced a significant increase in serum creatine kinase levels relative to those in laparotomized controls (2,530 +/- 530 vs. 389 +/- 64 IU/L, mean +/- SEM; p < 0.005). In the isolated perfused rat liver, 60-min ischemia induced early (< or = 3 min) creatine kinase and AST release (0.87 +/- 0.14 vs. 0.08 +/- 0.01 IU/min/gm liver, respectively). A similar phenomenon was observed after 24-hr or 48-hr hypothermic conservation in University of Wisconsin solution. Electrophoretic analysis and immunoinhibition studies showed that creatine kinase activity comprised creatine kinase-BB (approximately 50%) a...Continue Reading

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Citations

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D K DharN Nagasue
Mar 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J J LemastersR G Thurman
Apr 1, 2001·Journal of the American Aging Association·A ColantoniE J Kovacs
Jun 1, 1994·Free Radical Biology & Medicine·W R MathewsH Jaeschke
Dec 28, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·F X GalenJ P Clot
Dec 6, 2000·Journal of Gastroenterology and Hepatology·C CharrueauL Cynober
Nov 14, 1997·Transplantation·S SatohY Yamaoka
May 24, 2011·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·L S Nersesova
Mar 8, 2005·BMC Gastroenterology·Georg MeffertMarkus Wyss
Oct 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Markus KredelChristian Wunder
May 23, 2012·The Journal of Surgical Research·Christine CharrueauEric Savier
Jan 15, 2014·International Journal of Cancer. Journal International Du Cancer·Kenichiro EnookuHitoshi Ikeda
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Sugano, T Suzuki
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A Brass, M G Mody
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S D MalnickA M Kaye
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ShimizuR E Falk
Jul 6, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ayu NagamatsuNaoto Shiba

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