Creatine supplementation alters insulin secretion and glucose homeostasis in vivo

Metabolism: Clinical and Experimental
K B RooneyCampbell H Thompson

Abstract

Dietary creatine supplementation has been used to improve skeletal muscle performance. However, dietary creatine manipulation also affects glucose homeostasis. The aim of this study was to investigate the effect of dietary creatine supplementation on insulin secretion, glucose tolerance, and quadriceps glycogen metabolism in chow-fed rats. Forty-eight rats in total were divided into 2 groups of 24 and were then subdivided into 6 groups of 8. Rats were fed a diet supplemented with 0% (CON) or 2% (CREAT) creatine for 2, 4, or 8 weeks. At these 3 time points an oral glucose tolerance test was performed. Two days later, rats were euthanized and the pancreas and quadriceps muscles were collected. The peak insulin response to a glucose challenge was significantly elevated after both 4 (CON 327 +/- 72 v CREAT 735 +/- 140 pmol/L, P =.01) and 8 (CON 248 +/- 48 v CREAT 588 +/- 136 pmol/L, P =.02) weeks. Fasting insulin levels were also increased by creatine supplementation for 8 weeks (CON 78 +/- 14 v CREAT 139 +/- 14 pmol/L, P =.01). Glucose tolerance was not affected until 8 weeks at which point the peak plasma glucose was elevated in the creatine supplemented group (CON 10.1 +/- 0.6 v CREAT 13.5 +/- 1.5 mmol/L, P =.05). A significant ...Continue Reading

Citations

Oct 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patricia J AllenPerry F Renshaw
Mar 23, 2011·Amino Acids·Ralf JägerRichard B Kreider
Apr 17, 2020·Diabetes Care·Jagadish VangipurapuMarkku Laakso
Dec 3, 2011·Medicinal Research Reviews·Luisa PerassoMaurizio Balestrino
Jun 9, 2015·Nutrition & Metabolism·Yasuhito ShimadaToshio Tanaka
Jan 1, 2020·Genes & Nutrition·Michael B Williams, Stephen A Watts
Feb 7, 2003·American Journal of Physiology. Cell Physiology·Jeffrey J Brault, Ronald L Terjung
Apr 12, 2013·Journal of Bioenergetics and Biomembranes·Craig BeallMichael L J Ashford
Jun 17, 2016·Amino Acids·Camila Lemos PintoJoão Felipe Mota
Jan 25, 2003·Medicine and Science in Sports and Exercise·Jackie E N NewmanRodney J Snow
Mar 4, 2003·Journal of Applied Physiology·Jeffrey J BraultRonald L Terjung
Oct 15, 2003·Arthritis and Rheumatism·Virginia B KrausNancy B Allen
Oct 1, 2010·Medicine and Science in Sports and Exercise·Bruno GualanoAntonio Herbert Lancha
Feb 13, 2021·Nutrients·Marina Yazigi SolisBruno Gualano
Feb 13, 2021·Nutrients·Richard B Kreider, Jeffery R Stout
Mar 31, 2005·Metabolism: Clinical and Experimental·Alexandra J BuckleyCampbell H Thompson

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