PMID: 11897886Mar 19, 2002Paper

Creatine supplementation: exploring the role of the creatine kinase/phosphocreatine system in human muscle

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée
Peter HespelE A Richter

Abstract

The effect of oral creatine supplementation on high-intensity exercise performance has been extensively studied over the past ten years and its ergogenic potential in young healthy subjects is now well documented. Recently, research has shifted from performance evaluation towards elucidating the mechanisms underlying enhanced muscle functional capacity after creatine supplementation. In this review, we attempt to summarise recent advances in the understanding of potential mechanisms of action of creatine supplementation at the level of skeletal muscle cells. By increasing intracellular creatine content, oral creatine ingestion conceivably stimulates operation of the creatine kinase (CK)/phosphocreatine (PCr) system, which in turn facilitates muscle relaxation. Furthermore, evidence is accumulating to suggest that creatine supplementation can beneficially impact on muscle protein and glycogen synthesis. Thus, muscle hypertrophy and glycogen supercompensation are candidate factors to explain the ergogenic potential of creatine ingestion. Additional issues discussed in this review are the fibre-type specificity of muscle creatine metabolism, the identification of responders versus non-responders to creatine intake, and the scienti...Continue Reading

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Citations

Apr 25, 2012·Endocrine·Scott C ForbesDarren G Candow
Apr 8, 2004·Toxicology Letters·Mark A Brudnak
Aug 2, 2005·Pharmacology & Therapeutics·Hoon RyuRobert J Ferrante
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·T Peter Stein, Douglas R Bolster
Feb 25, 2005·American Journal of Physiology. Endocrinology and Metabolism·Wim DeravePeter Hespel
Jul 20, 2006·American Journal of Physiology. Endocrinology and Metabolism·Wim DeravePeter Hespel
Apr 1, 2003·Journal of Applied Physiology·Bert O EijndePeter Hespel
Jun 12, 2019·Nutrition and Cancer·Zoltan A TorokDavid S Hydock

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