Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling

European Journal of Nutrition
Paola Sanches CellaRafael Deminice

Abstract

The aim of this study was to investigate the effects of creatine supplementation on muscle wasting in Walker-256 tumor-bearing rats. Wistar rats were randomly assigned into three groups (n = 10/group): control (C), tumor bearing (T), and tumor bearing supplemented with creatine (TCr). Creatine was provided in drinking water for a total of 21 days. After 11 days of supplementation, tumor cells were implanted subcutaneously into T and TCr groups. The animals' weight, food and water intake were evaluated along the experimental protocol. After 10 days of tumor implantation (21 total), animals were euthanized for inflammatory state and skeletal muscle cross-sectional area measurements. Skeletal muscle components of ubiquitin-proteasome pathways were also evaluated using real-time PCR and immunoblotting. The results showed that creatine supplementation protected tumor-bearing rats against body weight loss and skeletal muscle atrophy. Creatine intake promoted lower levels of plasma TNF-α and IL-6 and smaller spleen morphology changes such as reduced size of white pulp and lymphoid follicle compared to tumor-bearing rats. In addition, creatine prevented increased levels of skeletal muscle Atrogin-1 and MuRF-1, key regulators of muscle ...Continue Reading

References

Jan 10, 2002·Biochemical and Biophysical Research Communications·John M LawlerScott Demaree
Mar 26, 2002·Cancer Letters·Maria Cristina C Gomes-Marcondes, Michael J Tisdale
Jun 19, 2003·British Journal of Pharmacology·Akihiro NomuraKiyohisa Sekizawa
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M S AokiA S Moriscot
Oct 21, 2006·Journal of Applied Physiology·Luciana Gomes MenezesJosé A Baddini Martinez
Nov 21, 2007·Biochimica Et Biophysica Acta·Chiara GuidiVilberto Stocchi
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Benjamin H L Tan, Kenneth C H Fearon
Aug 15, 2008·American Journal of Physiology. Cell Physiology·Jennifer S MoylanMichael B Reid
Aug 21, 2008·Pflügers Archiv : European journal of physiology·Kristen A BaltgalvisJames A Carson
Dec 17, 2008·The British Journal of Nutrition·Rafael DeminiceAlceu Afonso Jordao
Jan 9, 2009·Journal of Strength and Conditioning Research·Adam P W JohnstonDarren G Candow
Mar 3, 2009·Amino Acids·Bruno GualanoAntonio Herbert Lancha Junior
Jul 28, 2009·Mutation Research·Carmela FimognariPatrizia Hrelia
Sep 11, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Giorgos K SakkasKathleen Mulligan
Dec 30, 2009·International Journal of Cancer. Journal International Du Cancer·Fabio PennaPaola Costelli
Apr 20, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·David J Glass
Sep 28, 2010·Exercise and Sport Sciences Reviews·James A Carson, Kristen A Baltgalvis
Nov 26, 2010·Muscle & Nerve·Flávia A GuarnierRubens Cecchini
Mar 16, 2011·Amino Acids·Piero SestiliC Fimognari
Mar 31, 2011·Amino Acids·Theo WallimannUwe Schlattner
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Karsten LenkVolker Adams
Sep 2, 2011·The Journal of Nutrition·Rafael DeminiceJohn T Brosnan
Jan 3, 2012·Seminars in Cancer Biology·Frances R Balkwill, Alberto Mantovani
Jan 20, 2012·Skeletal Muscle·Joffrey De LarichaudyGeorges Némoz
Jan 21, 2012·International Journal of Sports Medicine·H FonsecaJ A Duarte
Mar 16, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Yichen Wang, Jeffrey E Pessin
Jun 19, 2013·The International Journal of Biochemistry & Cell Biology·N JohnsK C H Fearon
Oct 8, 2014·Nature Reviews. Cancer·Josep M ArgilésFrancisco J López-Soriano
Oct 17, 2014·Current Opinion in Supportive and Palliative Care·Aditi A Narsale, James A Carson
Oct 11, 2015·Bone·Priya Londhe, Denis C Guttridge
Dec 15, 2015·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Rahman RahimiZivar Salehi
Feb 14, 2016·Amino Acids·P L Campos-FerrazA H Lancha
Feb 26, 2016·Free Radical Biology & Medicine·Scott K PowersAshley J Smuder
Mar 1, 2016·Biochimica Et Biophysica Acta·Juliana MagdalonWilliam T Festuccia
May 6, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Camila Souza PadilhaRafael Deminice

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Citations

May 10, 2019·Neurotoxicity Research·Eduardo Peil Marques, Angela T S Wyse
Jan 9, 2021·Frontiers in Nutrition·Wouter R P H van de WorpRamon C J Langen
Dec 18, 2020·Frontiers in Physiology·Justine M WebsterRamon C J Langen
Feb 13, 2021·Nutrients·Richard B Kreider, Jeffery R Stout
Oct 26, 2020·Diabetologia·Yohei TomitaYoshihiko Usui
Jul 27, 2021·Animal Reproduction·Nayara Rodrigues RochaCarlos Eduardo Bezerra de Moura
Mar 19, 2021·Medicine and Science in Sports and Exercise·Camila S PadilhaRafael Deminice
Jul 30, 2021·Biogerontology·Alexandra Moreira-PaisJosé A Duarte

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