Creating artificial lymphoid tissues to study immunity and hematological malignancies

Current Opinion in Hematology
Shivem B Shah, Ankur Singh

Abstract

The specialized microenvironments of lymphoid tissue affect immune cell function and progression of disease. However, current animal models are low throughput and a large number of human diseases are difficult to model in animals. Animal models are less amenable to manipulation of tissue niche components, signalling pathways, epigenetics, and genome editing than ex vivo models. On the other hand, conventional 2D cultures lack the physiological relevance to study precise microenvironmental interactions. Thus, artificial tissues are being developed to study these interactions in the context of immune development, function, and disease. New bone marrow and lymph node models have been created to, respectively, study microenvironmental interactions in hematopoiesis and germinal center-like biology. These models have also been extended to understand the effect of these interactions on the progression and therapeutic response in leukemia, multiple myeloma, and lymphoma. 3D in-vitro immune models have elucidated new cellular, biochemical, and biophysical interactions as potential regulatory mechanisms, therapeutic targets, or biomarkers that previously could not be studied in animal models and conventional 2D cultures. Incorporation of...Continue Reading

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Citations

Jan 4, 2019·Advanced Healthcare Materials·Wujin SunAli Khademhosseini
Jun 8, 2019·SLAS Technology·Mosfera A ChowduryEdmond W K Young
Feb 29, 2020·Tissue Engineering. Part B, Reviews·Ishani D PremaratneJason A Spector
Oct 20, 2020·Small Methods·Sushila MaharjanYu Shrike Zhang
Jan 5, 2021·Frontiers in Oncology·Cristina Scielzo, Paolo Ghia
Dec 28, 2019·Biomaterials·Daniel Naveed TavakolThomas Braschler
May 21, 2021·Frontiers in Immunology·Francesca Vittoria SbranaCristina Scielzo

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