Creating Biomimetic Anisotropic Architectures with Co-Aligned Nanofibers and Macrochannels by Manipulating Ice Crystallization

ACS Nano
Linpeng FanXungai Wang

Abstract

The continuous evolution of tissue engineering scaffolds has been driven by the desire to recapitulate structural features and functions of the natural extracellular matrix (ECM). However, it is still an extreme challenge to create a three-dimensional (3D) scaffold with both aligned nanofibers and aligned interconnected macrochannels to mimic the ECM of anisotropic tissues. Here, we develop a facile strategy to create such a scaffold composed of oriented nanofibers and interconnected macrochannels in the same direction, with various natural polymers typically used for tissue regeneration. The orientation of nanofibers and interconnected macrochannels can be easily tuned by manipulating ice crystallization. The scaffold demonstrates both structural and functional features similar to the natural ECM of anisotropic tissues. Taking silk fibroin as an example, the scaffold with radially oriented nanofibers and interconnected macrochannels is more efficient for capturing cells and promoting the growth of both nonadherent embryonic dorsal root ganglion neurons (DRGs) and adherent human umbilical vein endothelial cells (HUVECs) compared to the widely used scaffold types. Interestingly, DRGs and neurites on the SF scaffold demonstrate a...Continue Reading

References

Apr 14, 1999·Neurosurgery·G A GrantM Kliot
Feb 9, 2002·Science·Martin E Schwab
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·R S KirtonD S Loiselle
Nov 19, 2005·Science·Molly M Stevens, Julian H George
Feb 7, 2006·Biomaterials·Chunmei LiDavid L Kaplan
Oct 6, 2007·Advanced Drug Delivery Reviews·Catherine P BarnesGary L Bowlin
Aug 10, 2010·Journal of Biomedical Materials Research. Part a·Xiao LiuGordon G Wallace
Oct 25, 2012·Tissue Engineering. Part a·Yi ShenRobert Jeffery Marano
Oct 22, 2013·Nature Materials·Timothy L DowningSong Li
Jan 25, 2014·Biomaterials·Mohammad R BadrossamayKevin Kit Parker
Feb 20, 2015·Nature Communications·Ovijit ChaudhuriDavid J Mooney
Mar 18, 2015·Nature Reviews. Rheumatology·Benjamin D Smith, Daniel A Grande
Mar 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dekel RosenfeldShulamit Levenberg
Jan 11, 2017·Tissue Engineering. Part a·Benjamin B RothrauffRocky S Tuan
Mar 23, 2017·Angewandte Chemie·Bernhard BaumannJürgen Groll
Oct 13, 2017·ACS Applied Materials & Interfaces·Serge OstrovidovAli Khademhosseini
Jan 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·S SayyarG G Wallace

❮ Previous
Next ❯

Citations

Apr 16, 2021·Advanced Science·Qian-Qian WanKai Jiao
Apr 24, 2021·Nature Communications·Linpeng FanXungai Wang
May 18, 2021·Bioactive Materials·Wen XueBin Duan
Aug 26, 2020·ACS Applied Materials & Interfaces·Tao MeiDong Wang
Jan 15, 2020·Biomacromolecules·Xiaoyi ZhangDavid L Kaplan
Dec 4, 2021·ACS Biomaterials Science & Engineering·San Seint Seint AyeJing-Liang Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.