PMID: 9427661Mar 7, 1998Paper

Creating novel enzymes by applied molecular evolution

Chemistry & Biology
A SkandalisL A Loeb

Abstract

Recent molecular techniques have made it feasible to simulate evolutionary processes and apply in vitro selection to evolve enzymes with novel properties that may have potential benefits for medical and industrial applications. The characterization of such mutants has also provided new insights into how molecular structure determines enzyme function.

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Apr 7, 1998·Nature Biotechnology·L P Encell, L A Loeb
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