Creating three dimensional models of Alzheimer's disease

3D Printing in Medicine
Matthew MarksDavid Jones

Abstract

Alzheimer's disease prevalence will reach epidemic proportions in coming decades. There is a need for impactful educational materials to help patients, families, medical practitioners, and policy makers understand the nature and impact of the disease. Defining an effective workflow to create such models from existing segmentation tools will be a valuable contribution in creating these patient-specific models. A step-by-step workflow was developed and used to take patients' Digital Imaging and Computing in Medicine magnetic resonance brain images through a process resulting in illustrative 3D-printed brain and hippocampus models that clearly demonstrate the progressive degenerative changes caused by Alzheimer's disease. We outline the specific technical steps of auto-segmentation, manual smoothing, Standard Triangle Language file customization, and 3D printing used to create these models. Our explicated workflow can create effective models of Alzheimer's brains that can be used in patient education, medical education, and policy forums.

References

Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Apr 30, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Otto PedrazaRobert J Ivnik
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Aug 19, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marina BoccardiUNKNOWN EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation
Mar 4, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Giovanni B Frisoni, Clifford R Jack

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Citations

May 22, 2020·Journal of Polymers and the Environment·Alina GhilanVlad Mihai Chiriac
Jul 10, 2021·Advanced Science·Zhongboyu JinYong He

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Software Mentioned

Materialise 3 - Matic
Medical Reality Markup Language ( MRML
Slicer
SPM
HarP
ADNI
3D
VeroClear

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