PMID: 616039Apr 1, 1977Paper

Creatinine clearance, urinary excretion of glomerular basement membrane antigens and renal histology in congenital nephrotic syndrome of Finnish type

Scandinavian Journal of Clinical and Laboratory Investigation
N P Huttunen

Abstract

The endogenous creatinine clearance and urinary excretion rate of glomerular basement membrane (GBM) antigens were followed from 2 to 19 months in fifteen patients with congenital nephrotic syndrome (CNF). The quantitative examination of renal morphology was made on fourteen of these patients. Creatinine clearance increased during the first few months of life and thereafter gradually decreased. The urinary excretion rate of GBM antigens rose during the course of the disease. The creatinine clearance did not correlate significantly with glomerular fibrosis but it did correlate with tubular atrophy and interstitial fibrosis. The urinary excretion of GBM antigens correlated significantly with glomerular and interstitial fibrosis and with tubular atrophy. It is concluded that there is a clear progress in the disease and the renal histological changes probably are caused by accumulation of GBM material in glomeruli.

References

May 1, 1976·Archives of Disease in Childhood·N P Huttunen
Jan 1, 1973·Nephron·N HallmanJ Rapola
May 1, 1971·Acta paediatrica Scandinavica·J Rapola, E Savilahti
Dec 1, 1969·The Journal of Experimental Medicine·J J McPhaul, F J Dixon

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Citations

Sep 1, 1979·Kidney International·E Rosenmann, J H Boss
Feb 1, 1978·Archives of Disease in Childhood·E A BurgessJ Stern
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abhay N VatsMichael Mauer
Sep 1, 1979·Kidney International·N P HuttunenT M Barratt

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