Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old

World Journal of Nephrology
Carlos Guido MussoJuan Florencio Macías Núñez


RENAL PHYSIOLOGY IN THE HEALTHY OLDEST OLD HAS THE FOLLOWING CHARACTERISTICS, IN COMPARISON WITH THE RENAL PHYSIOLOGY IN THE YOUNG: a reduced creatinine clearance, tubular pattern of creatinine back-filtration, preserved proximal tubule sodium reabsorption and uric acid secretion, reduced sodium reabsorption in the thick ascending loop of Henle, reduced free water clearance, increased urea excretion, presence of medulla hypotonicity, reduced urinary dilution and concentration capabilities, and finally a reduced collecting tubules response to furosemide which expresses a reduced potassium excretion in this segment due to a sort of aldosterone resistance. All physiological changes of the aged kidney are the same in both genders.


Sep 10, 2014·Dental Clinics of North America·Chester W Douglass, Monik C Jiménez
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Related Concepts

Aldosterone Measurement
Creatinine Clearance Measurement
Entire Medulla Oblongata
Loop of Henle

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