Creation of a functional graded nanobiomembrane using a new electrospinning system for drug release control and an in vitro validation of drug release behavior of the coating membrane

Materials Science & Engineering. C, Materials for Biological Applications
Chan-Hee ParkCheol Sang Kim

Abstract

Functional graded nanobiomembranes (FGMs) with multiple layers were created by a single process using a novel electrospinning system equipped with a generator and a PCI type motion board as a controller in order to control the drug release rate. By varying physical apparatus-related parameters such as nozzle-to-collector distance via a robot and the collector moving velocity the FGMs were formed. For the membrane base layer, poly-(ε-caprolactone) (PCL) with paclitaxel (PTX) was dissolved in a solvent (dichloromethane, N,N-dimethylformamide) and electrospun. For the top layers, the PCL solution was electrospun according to the distance and FGM system parameters, which can move the collector location at a constant ratio. It was observed that pore size, porosity, and permeability were higher when the membrane was spun at the far distance. The top surface of FGM is more porous, rougher, more permeable, and more hydrophilic so as to be active to the surrounding tissue cells. Meanwhile, the porous inside membrane was as low as the membrane spun at a close distance. Thus it induced a slow drug release due to the internal structure of FGM, which is considered to be very effective for slow drug release as well as bioactivity and biocond...Continue Reading

References

Sep 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuling XuXiabin Jing
Apr 10, 2007·Colloids and Surfaces. B, Biointerfaces·Anindarupa ChunderLei Zhai
May 10, 2011·Expert Opinion on Drug Delivery·Lei LeiFei Lu
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Jagadeesh G HiremathPrasanthkumar Mura

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Citations

Feb 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mami HamoriNobuhito Shibata
Feb 3, 2016·Biological & Pharmaceutical Bulletin·Annisa RahmaHeni Rachmawati
May 26, 2018·Journal of Drug Targeting·Mengyao LiuGuangxi Zhai
Aug 19, 2017·Journal of Materials Science. Materials in Medicine·Arezoo KhosraviAlireza Karimi

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