Creation of a molecular genetic test system for early diagnosis and evaluation of the effectiveness of treatment of inflammatory periodontal diseases

Klinicheskaia laboratornaia diagnostika
E R TamarovaA I Bulgakova

Abstract

Inflammatory periodontal diseases represent a serious dental and general medical problem due to the high prevalence among the adult population, the presence of clinical forms leading to the destruction of the dentition and tooth loss, insufficient treatment effectiveness and the frequency of relapse, including in connection with the formation of biofilms. A molecular genetic test system has been developed to evaluate the content of periodontopathogenic microorganisms Porphyromonas gingivalis, Treponema denticola, Streptococcus oralis, Streptococcus sanguis and Streptococcus sobrinus in the contents of periodontal pockets. The analytical characteristics of the test system were determined, and testing was carried out on clinical samples of patients with chronic generalized periodontitis of moderate severity. The constructed diagnostic kit allowed us to conduct a comparative analysis of the effectiveness of various types of treatment of inflammatory periodontal diseases based on quantitative data on the content of bacteria in the contents of periodontal pockets.

References

Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Paul E KolenbranderRobert J Palmer
Mar 11, 2004·Journal of Periodontal Research·Atsuo AmanoNobushiro Hamada
Nov 15, 2011·The Journal of Evidence-based Dental Practice·Paul I Eke
Dec 24, 2011·PloS One·Sylvio RedanzBernd Kreikemeyer
May 9, 2012·Acta Odontologica Scandinavica·Priscila CorrainiFrancisco E Pustiglioni
Dec 6, 2014·Journal of Oral Microbiology·Georg ConradsAn-Ping Zeng
Dec 1, 2012·Probiotics and Antimicrobial Proteins·Elisa SalvettiGiovanna E Felis

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