Creative use of novel glucose-lowering drugs for type 2 diabetes: where will we head in the next 50 years?

Diabetologia
Bo Ahrén

Abstract

Research conducted over the last 50 years has produced discoveries on the importance of glucose control for reducing the risk of diabetic complications, the pathophysiology of type 2 diabetes, the development and validation of mechanistic glucose-lowering targets, and the preclinical and clinical development of individual drugs. This science established the different drug classes that are clinically used today in association with lifestyle changes for lowering glucose in type 2 diabetes. For the next 50 years, we can anticipate that science will explore (1) the use of current drugs and, as they become available, newly developed drugs in early (initial) oral combinations followed by intensification with injectable combinations when glycaemia deteriorates, (2) the validation of novel mechanistic biochemical and physiological targets, including indirect effects of future antiobesity drugs, and (3) the development of true disease-modifying strategies based on knowledge of islet cell biology and replacement. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).

References

Jun 20, 2008·Vascular Health and Risk Management·Bo Ahrén
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Jan 14, 2011·The American Journal of Medicine·Bernard Zinman
Jun 28, 2011·Lancet·Abd A TahraniAnthony H Barnett
May 3, 2013·Vascular Health and Risk Management·Bo Ahrén
Sep 10, 2013·Cardiovascular Diabetology·John R Petrie
Feb 26, 2014·World Journal of Diabetes·Bo Ahrén
Apr 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Philippe A HalbanGordon C Weir

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Citations

Feb 18, 2016·Expert Opinion on Investigational Drugs·André J Scheen
Aug 23, 2018·Diabetologia·Sally M Marshall
Jul 6, 2019·Frontiers in Endocrinology·Bo Ahrén
Jul 8, 2019·Metabolism: Clinical and Experimental·Johan Farngren, Bo Ahrén

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