PMID: 16640787DOI: 10.1186/1744-8069-2-15Apr 28, 2006Paper
CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain.
Molecular Pain
Hushan AoMin Zhuo
Abstract
Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.
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Methods Mentioned
BETA
transfection
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