CREB deficient mice show inhibition and low activity in novel environments without changes in stress reactivity

The European Journal of Neuroscience
Elaine K Hebda-BauerHuda Akil

Abstract

The ability to respond to unexpected or novel stimuli is critical for survival. Determining that a stimulus is indeed novel requires memory to ascertain its lack of familiarity. As the long-term synaptic changes involved in memory formation require the cAMP response element binding protein (CREB), we examined the extent to which CREB is involved in responses to novel environments. These environments typically trigger an endocrine stress response. Thus, we measured behavioural and stress hormone responses to three novel and one familiar environment in mice with a targeted disruption of the alpha and delta isoforms of the CREB gene (CREB(alphadelta-) deficient mice). We found CREB(alphadelta-) deficient mice to be less active and more inhibited in the elevated plus maze, open field, and light/dark box, without showing differences in anxiety-like behaviour. This inhibition is unique to novel environments because these mice display a normal phenotype in the home cage, a familiar environment. Although CREB(alphadelta-) deficient mice exhibit altered behaviour in novel environments, they show normal reactivity to mild and moderate stress as both basal and stress levels of corticosterone are similar to those of wild-type controls. Thi...Continue Reading

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Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wen-Hui CaiCraig M Powell
Jul 21, 2007·Genes, Brain, and Behavior·B C McKinneyG G Murphy
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