CREB phosphorylation and c-Fos expression in the hippocampus of rats during acquisition and recall of a socially transmitted food preference

Hippocampus
Renee A CountrymanPaul J Colombo

Abstract

In the present study, phosphorylation of cAMP-response element binding protein (pCREB) and expression of c-Fos were measured in the dorsal and ventral hippocampus, as well as in a control region, the retrosplenial cortex, of rats following acquisition and recall of a socially transmitted food preference (STFP). Behavioral analyses revealed that STFP-trained rats showed a stronger preference for the demonstrated food than did rats in social-control or odor-control conditions. Rats in a social + odor control condition displayed an intermediate preference that was not significantly different from either STFP-trained rats or the social- or odor-controls. Immunocytochemical analyses revealed increased pCREB-immunoreactivity (ir) in the ventral hippocampus of STFP-trained rats in comparisons with rats in all three control conditions and increased pCREB-ir in the dorsal hippocampus in comparisons with the social- and odor-control conditions. In contrast, c-Fos-ir was greater in the dorsal hippocampus of STFP-trained rats in comparisons with all three control conditions and greater in the ventral hippocampus than rats in the social- and odor-control conditions. Comparisons of pCREB-ir and c-Fos-ir were made also between STFP-trained ra...Continue Reading

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Citations

Nov 15, 2006·Learning & Memory·Núria Boix-TrelisMargarita Martí-Nicolovius
Oct 13, 2007·Journal of Integrative Neuroscience·Jason G Fleischer, Jeffrey L Krichmar
Jan 8, 2009·Physiological Reviews·Cristina M Alberini
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Feb 3, 2016·Frontiers in Behavioral Neuroscience·C K MulderE A Van der Zee
Mar 1, 2012·Frontiers in Neuroendocrinology·Elena CholerisMartin Kavaliers
May 16, 2009·Frontiers in Neuroendocrinology·Elena CholerisMartin Kavaliers
May 9, 2012·Journal of Neurochemistry·Gustavo P GuerraMaribel A Rubin
Aug 27, 2005·Neurobiology of Learning and Memory·Renee A CountrymanPaul J Colombo
Dec 3, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marta Portero-TresserraAnna Vale-Martínez
Aug 12, 2014·Behavioural Brain Research·Lisa KinnavaneJohn P Aggleton
Oct 31, 2018·Genes, Brain, and Behavior·Marie H Monfils, Laura A Agee
Sep 11, 2019·International Journal of Molecular Sciences·Jian PengLin-Jie Shi

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