CREB1 modulates the influence of childhood sexual abuse on adult's anger traits

Genes, Brain, and Behavior
R HaslerP Courtet

Abstract

Childhood maltreatment and genes underlie vulnerability to suicidal behaviours (SB), possibly by affecting the constitution of endophenotypes such as anger traits. The CREB protein has been implicated in antidepressant response, suicide and mood disorders in general. The aim of this study was to investigate if CREB1 gene is associated with SB and/or anger-related traits and if these associations are modulated by childhood maltreatment. Five hundred and thirty-four male suicide attempters and 357 male non-suicide attempters were genotyped for several polymorphisms within CREB1 gene. Four hundred and thirty-seven (156 non-suicide attempters and 281 suicide attempters) completed the State-Trait Anger Expression Inventory (STAXI) and 288 (265 suicide attempters and 23 controls) fulfilled the Childhood Trauma Questionnaire (CTQ). In total, 72 males had experienced childhood sexual abuse. Our results did not show any significant association between CREB1 and suicide behaviour. We found a significant interaction showing that CREB1 rs4675690 polymorphism modulated the effect of childhood sexual abuse on adulthood anger-out levels (P = 0.003). Sexually abused subjects carrying the CC genotype showed higher anger-out scores than T allele...Continue Reading

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Citations

Nov 1, 2012·European Archives of Psychiatry and Clinical Neuroscience·Niki AntypaDan Rujescu
Mar 29, 2013·Journal of Psychiatric Research·Hilario Blasco-FontecillaPhilippe Courtet
Dec 7, 2019·Neuroscience and Biobehavioral Reviews·Nelly Alia-KleinEdelyn Verona

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