PMID: 9159233Sep 1, 1996Paper

CREM: a transcriptional master switch during the spermatogenesis differentiation program

Frontiers in Bioscience : a Journal and Virtual Library
F Nantel, Paolo Sassone-Corsi

Abstract

Spermatogenesis is a complex differentiation process under the hormonal control of the hypothalamic-pituitary axis. The CREM gene encodes activators and repressors of cAMP-mediated gene transcription. The transcript corresponding to the activator isoform CREMtau is found at high levels in pachytene spermatocytes onwards. The CREMtau protein, however, is present only in post-meiotic spermatids where it activates the transcription of testis-specific genes, such as the protamines and transition proteins. Mice in which the CREM gene has been inactivated by homologous recombination have been generated. Homozygous male mutant mice are sterile and produce no spermatozoa. Histological analysis of the seminiferous tubules reveal a complete arrest of spermatogenesis at the first step of spermiogenesis. CREM deficiency results in the lack of post-meiotic gene expression and a ten-fold increase in apoptotic germ cells. These results demonstrate the essential role of CREM in spermatogenesis and are reminiscent of some cases of male infertility.

Citations

Jan 15, 2020·Molecular and Cellular Biology·Eric A GustafsonRichard N Freiman
Jun 20, 2012·Human Reproduction Update·Hui ChenHsiao Chang Chan
Jul 15, 2015·PLoS Genetics·W Stephen KistlerWalter Reith
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Sarah KimminsPaolo Sassone-Corsi
Jun 24, 2010·Expert Opinion on Therapeutic Targets·Sebastian Dworkin, Theo Mantamadiotis
Dec 11, 2013·International Journal of Endocrinology·Giovanna CacciolaGilda Cobellis
Sep 30, 2004·Anatomical Science International·Kiyotaka ToshimoriDinesh K Saxena
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Haiying ZhouRobert Tjian
May 14, 2009·Molecular Cancer Research : MCR·Julian RozenbergCharles Vinson

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